The comprehensive unit-based safety program (CUSP), originally developed by Dr. Peter Pronovost and others at Johns Hopkins, has been shown to improve safety culture in multiple clinical settings. This commentary describes the development of a quality improvement collaborative designed to facilitate the implementation of CUSP in a group of academic and community hospitals. In addition to discussing the mentorship and network learning aspects of the collaborative, the authors also provide detailed descriptions of the implementation process and barriers faced at each institution. A prior article explored the role of quality improvement collaboratives in enhancing safety. Dr. Pronovost talked about his work with checklists and the science of improving patient safety in a past AHRQ WebM&M interview.