Health profession schools are increasingly using interprofessional simulation-based education (IP-SBE) for learners to understand each other’s roles in team-based care. Learners’ ability to feel psychologically safe during IP-SBE is necessary for full learner participation. This scoping review analyzed 27 studies of psychological safety within IP-SBE. Learners were more likely to feel safe in well-designed simulations with facilitators who are experienced in pre- and de-briefing. Barriers to psychological safety included hierarchy, being observed, uncertainty, and poorly designed and delivered simulations.