Regulatory bodies, health systems, and researchers are continuously investigating methods to ensure safe opioid prescribing for patients with chronic pain. This study engaged clinicians, pharmacists, and independent prescribers to evaluate opioid prescribing scenarios and rate them as inappropriate, uncertain, or appropriate. Fifteen out of the 21 scenarios were rated as inappropriate (i.e., could result in harm to patients) and can be used to support decision making for appropriate prescribing and deprescribing for patients with chronic pain in primary care.