Effect of pharmacist email alerts on concurrent prescribing of opioids and benzodiazepines by prescribers and primary care managers: a randomized clinical trial.

Adam Sacarny; Elana Safran; Mary Steffel; Jacob R Dunham; Orolo D Abili; Lobat Mohajeri; Patricia T Oh; Alan Sim; Robert E Brutcher; Christopher Spevak

Study

Effect of pharmacist email alerts on concurrent prescribing of opioids and benzodiazepines by prescribers and primary care managers: a randomized clinical trial.

October 26, 2022

Sacarny A, Safran E, Steffel M, et al. JAMA Health Forum. 2022;3(9):e223378.

View more articles from the same authors.

Concurrent prescribing of opioids and benzodiazepines can put patients at increased risk of overdose. This randomized study found that pharmacist email alerts to clinicians caring for patients recently co-prescribed opioids and benzodiazepines did not reduce concurrent prescribing of these medications.

PubMed citation

Free full text

Related Resources From the Same Author(s)

Effect of different interventions to help primary care clinicians avoid unsafe opioid prescribing in opioid-naive patients with acute noncancer pain: a cluster randomized clinical trial.

September 7, 2022

Effect of medication reconciliation at hospital admission on 30-day returns to hospital: a randomized clinical trial.

October 6, 2021

Effect of prescriber notifications of patient’s fatal overdose on opioid prescribing at 4 to 12 months: a randomized clinical trial.

January 18, 2023

Effect of a multifaceted clinical pharmacist intervention on medication safety after hospitalization in persons prescribed high-risk medications: a randomized clinical trial.

March 17, 2021

Effect of cognitive aids on adherence to best practice in the treatment of deteriorating surgical patients: a randomized clinical trial in a simulation setting.

January 8, 2020

Electronic health record legal settlements in the US since the 2009 Health Information Technology for Economic and Clinical Health Act.

December 21, 2022

Cost of inpatient falls and cost-benefit analysis of implementation of an evidence-based fall prevention program.

February 1, 2023

Effect of a mobile app on prehospital medication errors during simulated pediatric resuscitation: a randomized clinical trial.

September 15, 2021

A new category of "never events"-ending harmful hospital policies.

November 9, 2022

Concordance of hospital ranks and category ratings using the current technical specification of US Hospital Star Ratings and reasonable alternative specifications.

August 31, 2022

Effect of pharmacist counseling intervention on health care utilization following hospital discharge: a randomized control trial.

June 8, 2016

The effect of structured medication review followed by face-to-face feedback to prescribers on adverse drug events recognition and prevention in older inpatients - a multicenter interrupted time series study.

August 10, 2022

The MedSafer study-electronic decision support for deprescribing in hospitalized older adults: a cluster randomized clinical trial.

February 2, 2022

Implementation of the I-PASS handoff program in diverse clinical environments: a multicenter prospective effectiveness implementation study.

November 16, 2022

Adverse events and hospital-acquired conditions associated with potential low-value care in Medicare beneficiaries.

August 11, 2021

Toward safer opioid prescribing in HIV care (TOWER): a mixed-methods, cluster-randomized trial.

June 22, 2022

Evaluation of a patient-centered fall-prevention tool kit to reduce falls and injuries: a nonrandomized controlled trial.

December 2, 2020

Patient Safety Innovations

Pharmacist-led mobile health intervention and transplant medication safety: a randomized controlled clinical trial.

April 7, 2022

Association of past and future paid medical malpractice claims.

March 1, 2023

Guidelines for opioid prescribing in children and adolescents after surgery: an expert panel opinion.

December 2, 2020

Racial differences in antibiotic prescribing by primary care pediatricians.

March 20, 2013

Clinical decision support improves the appropriateness of laboratory test ordering in primary care without increasing diagnostic error: the ELMO cluster randomized trial.

December 2, 2020

A randomized trial of a multifactorial strategy to prevent serious fall injuries.

July 29, 2020

Diagnostic errors, health disparities, and artificial intelligence: a combination for health or harm.

September 1, 2021

Evaluation of clinical practice guidelines on fall prevention and management for older adults: a systematic review.

January 12, 2022

Nonopioid directives: unintended consequences in the operating room.

June 29, 2022

The effects of rudeness, experience, and perspective-taking on challenging premature closure after pediatric ICU physicians receive hand-off with the wrong diagnosis: a randomized controlled simulation trial.

December 9, 2020

CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.

November 16, 2022

Seroprevalence of SARS-CoV-2 among frontline health care personnel in a multistate hospital network--13 academic medical centers, April-June 2020.

September 23, 2020

Incidence of nosocomial COVID-19 in patients hospitalized at a large US academic medical center.

October 21, 2020

Evaluating the safety of mental health-related prescribing in UK primary care: a cross-sectional study using the Clinical Practice Research Datalink (CPRD).

September 15, 2021

Optimizing Pediatric Patient Safety in the Emergency Care Setting.

October 19, 2022

Association of surgeon-patient sex concordance with postoperative outcomes,

December 22, 2021

The effects of leadership curricula with and without implicit bias training on graduate medical education: a multicenter randomized trial.

May 18, 2022

The effect of automated alerts on provider ordering behavior in an outpatient setting.

September 21, 2005

Evaluation of effectiveness and safety of pharmacist independent prescribers in care homes: cluster randomised controlled trial.

March 1, 2023

Effectiveness of pharmacist intervention to reduce medication errors and health-care resources utilization after transitions of care: a meta-analysis of randomized controlled trials.

July 19, 2017

Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) - a randomized controlled trial.

November 30, 2022

Personal formularies of primary care physicians across 4 health care systems.

August 4, 2021

Association of display of patient photographs in the electronic health record with wrong-patient order entry errors.

December 2, 2020

Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation.

April 1, 2020

Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions.

August 4, 2021

Evaluation of a Web-based education program on reducing medication dosing error: a multicenter, randomized controlled trial.

January 31, 2006

Rates of surgical consultations after emergency department admission in Black and White Medicare patients.

October 26, 2022

Association of patient and family reports of hospital safety climate with language proficiency in the US.

June 29, 2022

Renal medication-related clinical decision support (CDS) alerts and overrides in the inpatient setting following implementation of a commercial electronic health record: implications for designing more effective alerts.

February 17, 2021

Association of diagnostic stewardship for blood cultures in critically ill children with culture rates, antibiotic use, and patient outcomes: results of the Bright STAR Collaborative.

May 18, 2022

Prevalence of undiagnosed diabetes identified by a novel electronic medical record diabetes screening program in an urban emergency department in the US.

February 22, 2023

Structured override reasons for drug–drug interaction alerts in electronic health records.

May 15, 2019

A randomized clinical trial to compare the use of safety net enclosures with standard restraints in agitated hospitalized patients.

January 9, 2008

Characteristics of disease-specific and generic diagnostic pitfalls: a qualitative study.

February 9, 2022

Association of dose tapering with overdose or mental health crisis among patients prescribed long-term opioids.

August 25, 2021

Assessment of changes in visits and antibiotic prescribing during the Agency for Healthcare Research and Quality Safety Program for Improving Antibiotic Use and the COVID-19 Pandemic.

July 20, 2022

Clinical features and preventability of delayed diagnosis of pediatric appendicitis.

September 29, 2021

Analysis of variation between diagnosis at admission vs discharge and clinical outcomes among adults with possible bacteremia.

July 13, 2022

The effect of medication reconciliation via a patient portal on medication discrepancies: a randomized noninferiority study.

January 26, 2022

Guidance for health care leaders during the recovery stage of the COVID-19 pandemic: a consensus statement.

July 28, 2021

We asked the experts: the WHO Surgical Safety Checklist and the COVID-19 pandemic: recommendations for content and implementation adaptations.

March 17, 2021

Improving communication and response to clinical deterioration to increase patient safety in the intensive care unit.

October 19, 2022

Pharmacist-led intervention on the reduction of inappropriate medication use in patients with heart failure: a systematic review of randomized trials and non-randomized intervention studies.

August 18, 2021

A systematic review of the effect of telepharmacy services in the community pharmacy setting on care quality and patient safety.

June 30, 2021

Complexity and challenges of the clinical diagnosis and management of Long COVID.

November 30, 2022

Prescribing decision making by medical residents on night shifts: a qualitative study.

November 9, 2022

Impact of digitally acquired peer diagnostic input on diagnostic confidence in outpatient cases: a pragmatic randomized trial.

December 2, 2020

Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016

March 3, 2017

Associations of person-related, environment-related and communication-related factors on medication errors in public and private hospitals: a retrospective clinical audit.

November 17, 2021

Overriding drug-drug interaction alerts in clinical decision support systems: a scoping review.

September 7, 2022

The randomized AMBORA trial: impact of pharmacological/pharmaceutical care on medication safety and patient-reported outcomes during treatment with new oral anticancer agents.

April 21, 2021

Clinician distress and inappropriate antibiotic prescribing for acute respiratory tract infections: a retrospective cohort study.

May 11, 2022

Assessment of health information technology-related outpatient diagnostic delays in the US Veterans Affairs health care system: a qualitative study of aggregated root cause analysis data.

July 22, 2020

Association of default electronic medical record settings with health care professional patterns of opioid prescribing in emergency departments: A randomized quality improvement study

February 12, 2020

Influence of opioid prescription policy on overdoses and related adverse effects in a primary care population.

May 19, 2021

Assessment of overuse of medical tests and treatments at US hospitals using Medicare claims.

May 19, 2021

Redeployment of health care workers in the COVID-19 pandemic: a qualitative study of health system leaders' strategies.

May 19, 2021

The critical role of health information technology in the safe integration of behavioral health and primary care to improve patient care.

November 10, 2021

A scoping review of real-time automated clinical deterioration alerts and evidence of impacts on hospitalised patient outcomes.

August 3, 2022

Association between mobile telephone interruptions and medication administration errors in a pediatric intensive care unit.

January 15, 2020

The safety of inpatient health care.

January 25, 2023

Effects of a refined evidence-based toolkit and mentored implementation on medication reconciliation at 18 hospitals: results of the MARQUIS2 study.

May 19, 2021

A qualitative study of prescribing errors among multi-professional prescribers within an e-prescribing system.

December 23, 2020

An e-Delphi study to obtain expert consensus on the level of risk associated with preventable e-prescribing events.

April 13, 2022

Promoting patient and nurse safety: testing a behavioural health intervention in a learning healthcare system: results of the DEMEANOR pragmatic, cluster, cross-over trial.

March 2, 2022

Effect of Patient and Family Centered I-PASS on adverse event rates in hospitalized children with complex chronic conditions.

March 8, 2023

Nurses' influence on consumers' experience of safety in acute mental health units: a qualitative study.

December 16, 2020

eSIMPLER: a dynamic, electronic health record-integrated checklist for clinical decision support during PICU daily rounds.

June 16, 2021

Patient Safety Innovations

eSIMPLER: a dynamic, electronic health record-integrated checklist for clinical decision support during PICU daily rounds.

April 7, 2022

Determinants of burnout and other aspects of psychological well-being in healthcare workers during the Covid-19 pandemic: a multinational cross-sectional study.

May 5, 2021

Healthcare failure mode and effect analysis (HFMEA) as an effective mechanism in preventing infection caused by accompanying caregivers during COVID-19-experience of a city medical center in Taiwan.

January 27, 2021

A national mixed-methods evaluation of preparedness for general surgery residency and the association with resident burnout.

September 2, 2020

Effect of automated unit dose dispensing with barcode scanning on medication administration errors: an uncontrolled before-and-after study.

December 1, 2021

The effect of the fit between organizational culture and structure on medication errors in medical group practices.

February 7, 2007

Effects of racial bias in pulse oximetry on children and how to address algorithmic bias in clinical medicine.

April 5, 2023

Comparison of health care worker satisfaction before vs after implementation of a communication and optimal resolution program in acute care hospitals.

April 5, 2023

Understanding context specificity: the effect of contextual factors on clinical reasoning.

September 2, 2020

Adherence to national guidelines for timeliness of test results communication to patients in the Veterans Affairs health care system.

May 4, 2022

Prevalence and sources of duplicate information in the electronic medical record.

October 12, 2022

Health care-associated infections among critically ill children in the US, 2013-2018.

October 28, 2020

Association between parent comfort with English and adverse events among hospitalized children.

November 11, 2020

Health system redesign of cardiac monitoring oversight to optimize alarm management, safety, and staff engagement.

December 14, 2022

Improved medication management with introduction of a perioperative and prescribing pharmacist service.

August 12, 2020

Related Resources

unDerstandIng the cauSes of mediCation errOrs and adVerse drug evEnts for patients with mental illness in community caRe (DISCOVER): a qualitative study.

February 28, 2024

Multicomponent pharmacist intervention did not reduce clinically important medication errors for ambulatory patients initiating direct oral anticoagulants.

October 11, 2023

Handling polypharmacy--a qualitative study using focus group interviews with older patients, their relatives, and healthcare professionals.

September 13, 2023

Activating pharmacists to reduce the frequency of medication-related problems (ACTMed): a stepped wedge cluster randomised trial.

August 30, 2023

Healthcare fragmentation, multimorbidity, potentially inappropriate medication, and mortality: a Danish nationwide cohort study.

August 30, 2023

Risk Evaluation and Mitigation Strategy (REMS) Programs and Medication Safety: Parts I and II.

August 9, 2023

Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics.

June 7, 2023

Danger in discharge summaries: abbreviations create confusion for both author and recipient.

May 31, 2023

Identification of patient safety threats in a post-intensive care clinic.

May 31, 2023

Making polypharmacy safer for children with medical complexity.

April 5, 2023

WebM&M Cases

Duplicate Therapies in Retail Pharmacy

March 15, 2023

Pharmacists reducing medication risk in medical outpatient clinics: a retrospective study of 18 clinics.

March 8, 2023

Association between opioid tapering and subsequent health care use, medication adherence, and chronic condition control.

March 1, 2023

Defining and enhancing collaboration between community pharmacists and primary care providers to improve medication safety.

February 22, 2023

Medication use evaluation of high-dose long-term opioid de-prescribing in multiple Veterans Affairs medical centers.

January 18, 2023

Effect of prescriber notifications of patient’s fatal overdose on opioid prescribing at 4 to 12 months: a randomized clinical trial.

January 18, 2023

Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: multiple interrupted time series study.

January 11, 2023

Lessons learned in implementing a chronic opioid therapy management system.

December 21, 2022

Factors that affect opioid quality improvement initiatives in primary care: insights from ten health systems.

December 14, 2022

Understanding factors that could influence patient acceptability of the use of the PINCER intervention in primary care: a qualitative exploration using the Theoretical Framework of Acceptability.

November 9, 2022

Medication adverse events in the ambulatory setting: a mixed-methods analysis.

October 26, 2022

Effect of different interventions to help primary care clinicians avoid unsafe opioid prescribing in opioid-naive patients with acute noncancer pain: a cluster randomized clinical trial.

September 7, 2022

Influence of a general practice pharmacist on medication management for patients at risk of medicine-related harm: a qualitative evaluation.

July 20, 2022

Long-term risk of overdose or mental health crisis after opioid dose tapering.

July 13, 2022

Changes to primary care delivery during the COVID-19 pandemic and perceived impact on medication safety: a survey study.

June 29, 2022

Toward safer opioid prescribing in HIV care (TOWER): a mixed-methods, cluster-randomized trial.

June 22, 2022

What is the medication iatrogenic risk in elderly outpatients for chronic pain?

June 1, 2022

Exploration of prescribing error reporting across primary care: a qualitative study.

April 13, 2022

Annual Perspective

Annual Perspective: Topics in Medication Safety

March 31, 2022

Medication errors' causes analysis in home care setting: a systematic review.

February 9, 2022

See More About The Topic

Ambulatory Clinic or Office

Quality and Safety Professionals

Primary Care

Community Pharmacy

Medication Errors/Preventable Adverse Drug Events

Effect of pharmacist email alerts on concurrent prescribing of opioids and benzodiazepines by prescribers and primary care managers: a randomized clinical trial.

Pharmacist-led mobile health intervention and transplant medication safety: a randomized controlled clinical trial.

eSIMPLER: a dynamic, electronic health record-integrated checklist for clinical decision support during PICU daily rounds.

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

Effect of pharmacist email alerts on concurrent prescribing of opioids and benzodiazepines by prescribers and primary care managers: a randomized clinical trial.

Pharmacist-led mobile health intervention and transplant medication safety: a randomized controlled clinical trial.

eSIMPLER: a dynamic, electronic health record-integrated checklist for clinical decision support during PICU daily rounds.

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

Submit Your Innovations

Continue as a Guest

Continue Logged In

Submit Your Innovations

Continue as a Guest

Continue logged in

New Users to the PSNet site