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Patient outcomes after opioid dose reduction among patients with chronic opioid therapy.
January 12, 2022
Hallvik SE, El Ibrahimi S, Johnston K, et al. Pain. 2022;163(1):83-90.
Opiates are a high-risk medication due to the potential for adverse events including misuse and overdose. This study examined whether dose reduction or discontinuation after high-dose chronic opioid therapy is associated with suicide, overdose, or other adverse events. In this cohort of Oregon Medicaid recipients, discontinuation increased the risk for suicide or opioid-related adverse events. Patients with stable or increasing doses had an increased risk of overdose.
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