Prescribing for the elderly. Part I: Sensitivity of the elderly to adverse drug reactions.
Nolan L, O'Malley K. J Am Geriatr Soc. 1988;36:142-149.
This study reviewed existing evidence in order to evaluate the relationship between chronological age and
adverse drug reactions
. The authors provide a narrative summary and tables to illustrate trends noted in the more robust inpatient literature and the somewhat scarce outpatient literature for this relationship. Factors thought to contribute to adverse drug events are discussed, including multiple drug therapy, the presence of multiple disorders, severity of disease, and altered pharmacokinetics and pharmacodynamics. The findings suggest that elderly patients are not likely to experience an adverse reaction simply because of their age. Future studies must account for the factors more likely to impact poor outcomes with drug therapy.
Concealed renal insufficiency and adverse drug reactions in elderly hospitalized patients.
Corsonello A, Pedone C, Corica F, Mussi C, Carbonin P, Antonelli Incalzi R, for the Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA) Investigators. Arch Intern Med. 2005;165:790-795.
Predicting and preventing adverse drug reactions in the very old.
Merle L, Laroche ML, Dantoine T, Charmes JP. Drugs Aging. 2005;22:375-392.
Use of the Beers criteria to predict adverse drug reactions among first-visit elderly outpatients.
Chang CM, Liu PY, Yang YH, Yang YC, Wu CF, Lu FH. Pharmacotherapy. 2005;25:831-838.
Inappropriate drug use in the elderly: a nationwide register-based study.
Johnell K, Fastbom J, Rosén M, Leimanis A. Ann Pharmacother. 2007;41:1243-1248.
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