The landmark IOM report emphasized the role of high-functioning teams in promoting safe care. This systematic review analyzed 48 studies that evaluated the impact of simulation training, crew resource management training, interprofessional training, and teamwork training on team effectiveness. While the authors found that implementation of team training did improve the effectiveness of multidisciplinary teams in acute care settings, they identified only a few studies that provided high quality evidence on the impact of specific interventions. The authors highlight the challenges in analyzing this literature because of the heterogeneity of the interventions and the inability to measure the context in which they were implemented.