Reduction of catheter-related blood stream infections (CRBSIs) is an important patient safety goal, which was achieved with remarkable success in the Michigan Keystone project. This study similarly targeted CRBSIs and also demonstrated significant reductions in 174 intensive care units across the Veterans Administration (VA) health system. Improvements were correlated with local adherence to prevention bundles, while poorly performing sites were noted to lack functional teams, forcing functions, and effective feedback systems. The authors discuss their findings and specifically distinguish elements of their study from the Keystone project, including their nationwide ICU sample and a more centralized approach with data benchmarks and tools. They also point out the ability to leverage existing information technology infrastructure in the VA system that allows greater ease of sharing data and learning.