Enhanced information technology (IT) has been identified as a key component of improving patient safety, but development and implementation of health care IT systems have sometimes led to unintended consequences. In this study, the authors interviewed 31 health care IT stakeholders, ranging from IT developers to frontline clinicians, to identify priority areas for improving IT in the primary care setting. Interviewees voiced a strong interest in using IT for decision support but were frustrated with a perceived lack of attention to human factors engineering in current IT systems.