Providing patient-centered care continues to be a goal in both clinical settings and from a systems standpoint. While single-patient rooms have been associated with patients feeling safer, there is some debate about whether patients' satisfaction equates to their safety. This commentary advocates for single-patient rooms as a method to become more patient-centered, increase patient satisfaction, and reduce the incidence of nosocomial infections. The authors also point out important considerations with such a strategy, including costs and potential changes in workflow and related processes. However, they conclude that efforts at hospital design could have greater impact on patient safety and satisfaction than efforts at changing hospital culture.