@article{7893,
  author = {Jasperien van Doormaal and Patricia M L A van den Bemt and Rianne J. Zaal and Antoine C G Egberts and Bertil W. Lenderink and Jos G W Kosterink and Flora M. Haaijer-Ruskamp and Peter G M Mol},
  title = {The influence that electronic prescribing has on medication errors and preventable adverse drug events: an interrupted time-series study.},
  abstract = {<p><b>OBJECTIVE: </b>This study evaluated the effect of a Computerized Physician Order Entry system with basic Clinical Decision Support (CPOE/CDSS) on the incidence of medication errors (MEs) and preventable adverse drug events (pADEs).</p><p><b>DESIGN: </b>Interrupted time-series design.</p><p><b>MEASUREMENTS: </b>The primary outcome measurements comprised the percentage of medication orders with one or more MEs and the percentage of patients with one or more pADEs.</p><p><b>RESULTS: </b>Pre-implementation, the mean percentage of medication orders containing at least one ME was 55%, whereas this became 17% post-implementation. The introduction of CPOE/CDSS has led to a significant immediate absolute reduction of 40.3% (95% CI: -45.13%; -35.48%) in medication orders with one or more errors. Pre-implementation, the mean percentage of admitted patients experiencing at least one pADE was 15.5%, as opposed to 7.3% post-implementation. However, this decrease could not be attributed to the introduction of CPOE/CDSS: taking into consideration the interrupted time-series design, the immediate change was not significant (-0.42%, 95% CI: -15.52%; 14.68%) because of the observed underlying negative trend during the pre-CPOE period of -4.04% [95% CI: -7.70%; -0.38%] per month.</p><p><b>CONCLUSIONS: </b>This study has shown that CPOE/CDSS reduces the incidence of medication errors. However, a direct effect on actual patient harm (pADEs) was not demonstrated.</p>},
  year = {2009},
  journal = {J Am Med Inform Assoc},
  volume = {16},
  pages = {816-25},
  month = {12/2009},
  issn = {1527-974X},
  doi = {10.1197/jamia.M3099},
  language = {eng},
}