“Serious games” are becoming more prevalent in health care. This article describes a "serious game" PlayDecide for use of multidisciplinary healthcare teams in which the teams are presented with real-world case stories of events and incidents, incorporating the perspectives of healthcare professionals and patients. Players are tasked with exchanging and discussing perspectives and information, then working towards a shared group policy position around error reporting and patient safety. This study evaluated the use of the PlayDecide framework in two large urban academic medical centers and noted a significant change in error reporting behavior among junior faculty post-intervention.