Numerous interventions have been promoted to ensure adherence to evidence-based practices and patient safety measures, and yet their use in real-world settings remains inconsistent. This study used random safety audits in the intensive care unit (ICU) to detect errors of omission and deviations from best practices, correcting them in real time when possible. In unadjusted analysis, there were no significant differences in mortality between patients who were included in safety audits and those who were not. However, in adjusted analysis, included patients had lower mortality rates.