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PSNet: Patient Safety Network
Journal Article
Study

Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis.

Sun EC, Dixit A, Humphreys K, et al. BMJ (Clinical research ed.). 2017;356:j760.

Concurrent use of opioids and benzodiazepines increases risk for adverse drug events. This retrospective analysis of medical claims found that the risk of emergency department visit was greater for patients with concurrent use of these two medication classes compared to patients on opioids alone. This finding supports the recommendation to avoid coprescribing these two medication classes.