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Association of dose tapering with overdose or mental health crisis among patients prescribed long-term opioids.

Agnoli A, Xing G, Tancredi DJ, et al. Association of dose tapering with overdose or mental health crisis among patients prescribed long-term opioids. JAMA. 2021;326(5):411-119. doi: 10.1001/jama.2021.11013.

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August 25, 2021
Agnoli A, Xing G, Tancredi DJ, et al. JAMA. 2021;326(5):411-419.

Sudden discontinuation of opioids has been linked to increased patient harm. This observational study evaluated the link between tapering and overdose, and mental health crisis among patients who were receiving long-term opioid therapy. Patients who underwent dose tapering had an increased risk of overdose and mental health crisis compared to those who did not undergo dose tapering. 

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Agnoli A, Xing G, Tancredi DJ, et al. Association of dose tapering with overdose or mental health crisis among patients prescribed long-term opioids. JAMA. 2021;326(5):411-119. doi: 10.1001/jama.2021.11013.