This study describes the impact of a new patient safety curriculum targeting second-year medical students at a single institution. Investigators surveyed participating students before the curriculum, after the last session, and 1 year later to report changes over that time. The curriculum itself was a combination of lectures, panel discussions, and interactive sessions around themes that included error reporting, system versus human approaches, safety tools, and ethics and disclosure. Following the curriculum, students' knowledge scores improved, but several of these changes were not sustained at 1 year. The authors suggest that incorporation of patient safety education early in medical school can increase knowledge in this arena, but for the change to be sustained, it must take into account other and potentially countering components of students' educational experiences.