Provider burnout has been increasing, particularly since the start of the COVID-19 pandemic, and numerous interventions are being investigated to reduce it. This study used daily diaries from primary care physicians to investigate the association between breaks during the workday and burnout, well-being, and patient safety perceptions. Results indicate that taking a break is associated with lower disengagement that day and lower exhaustion the next day. A break that includes a positive interaction also improves perceptions of patient safety.