Drug-drug interactions and prescription appropriateness at hospital discharge: experience with COVID-19 patients.

Dario Cattaneo; Luca Pasina; Aldo Pietro Maggioni; Letizia Oreni; Federico Conti; Laura Pezzati; Giacomo Casalini; Cecilia Bonazzetti; Valentina Morena; Annalisa Ridolfo; Spinello Antinori; Cristina Gervasoni

Study

Drug-drug interactions and prescription appropriateness at hospital discharge: experience with COVID-19 patients.

April 21, 2021

Cattaneo D, Pasina L, Maggioni AP, et al. Drugs Aging. 2021;38(4):341-346.

View more articles from the same authors.

Older adults are at increased risk of hospitalization due to COVID-19 infections. This study examined the potential severe drug-drug interactions (DDI) among hospitalized older adults taking two or more medications at admission and discharge. There was a significant increase in prescription of proton pump inhibitors and heparins from admission to discharge. Clinical decision support systems should be used to assess potential DDI with particular attention paid to the risk of bleeding complications linked to heparin-based DDIs.

PubMed citation

Free full text

Related Resources From the Same Author(s)

Opioids and falls risk in older adults: a narrative review.

May 25, 2022

Scoping review of studies evaluating frailty and its association with medication harm.

June 22, 2022

Clinical characteristics and short-term outcomes of acute kidney injury missed diagnosis in older patients with severe COVID-19 in intensive care unit.

May 19, 2021

Overriding drug-drug interaction alerts in clinical decision support systems: a scoping review.

September 7, 2022

Improving the specificity of drug-drug interaction alerts: can it be done?

April 6, 2022

Older patients' engagement in hospital medication safety behaviours.

June 16, 2021

We asked the experts: the WHO Surgical Safety Checklist and the COVID-19 pandemic: recommendations for content and implementation adaptations.

March 17, 2021

Adverse health events related to self-medication practices among elderly: a systematic review.

May 31, 2017

Medication reconciliation in the geriatric unit: impact on the maintenance of post-hospitalization prescriptions.

October 13, 2021

Modification of potentially inappropriate prescribing following fall-related hospitalizations in older adults.

July 10, 2019

COVID-19 increased the risk of ICU-acquired bloodstream infections: a case-cohort study from the multicentric OUTCOMEREA network.

March 17, 2021

Overall performance of a drug-drug interaction clinical decision support system: quantitative evaluation and end-user survey.

April 13, 2022

Hospital acquired infections in surgical patients: impact of COVID-19-related infection prevention measures.

April 20, 2022

High-priority drug-drug interaction clinical decision support overrides in a newly implemented commercial computerized provider order-entry system: override appropriateness and adverse drug events.

May 20, 2020

Clinical reasoning in dire times- analysis of cognitive biases in clinical cases during the COVID-19 pandemic.

February 23, 2022

Effect of pharmacist counseling intervention on health care utilization following hospital discharge: a randomized control trial.

June 8, 2016

Flexibilization of science, cognitive biases, and the COVID-19 pandemic.

September 23, 2020

Remember that patient you saw last week: characteristics and frequency of patients experiencing anticipated and unanticipated death following ED discharge.

December 1, 2021

Structural racism and the COVID-19 experience in the United States.

July 7, 2021

Critical care clinicians' experiences of patient safety during the COVID-19 pandemic.

November 30, 2022

Hospital quality-review spending and patient safety: a longitudinal analysis using instrumental variables.

July 7, 2021

Post-discharge adverse events among African American and Caucasian patients of an urban community hospital.

July 15, 2020

Influence of opioid prescription policy on overdoses and related adverse effects in a primary care population.

May 19, 2021

Patient factors and hospital outcomes associated with atypical presentation in hospitalized older adults with COVID-19 during the first surge of the pandemic.

August 18, 2021

Ethical considerations and patient safety concerns for cancelling non-urgent surgeries during the COVID-19 pandemic: a review.

May 12, 2021

Impact of the COVID-19 pandemic on the experiences of hospitalized patients: a scoping review.

February 22, 2023

The influence of COVID-19 visitation restrictions on patient experience and safety outcomes: a critical role for subjective advocates.

July 14, 2021

To expand the evidence base about harms from tests and treatments.

September 15, 2021

COVID-19 and open notes: a new method to enhance patient safety and trust.

July 7, 2021

Initiatives to identify and mitigate medication errors in England.

April 8, 2015

Impact of COVID-19 on inpatient clinical emergencies: a single-center experience.

June 9, 2021

Critical care nurses’ physical and mental health, worksite wellness support, and medical errors.

July 14, 2021

Prevalence, nature, severity and preventability of adverse drug events in mental health settings: findings from the MedicAtion relateD harm in mEntal health hospitals (MADE) study.

August 11, 2021

The abrupt expansion of ambulatory telemedicine: implications for patient safety.

February 9, 2022

Implementation of simulation training during the COVID-19 pandemic: a New York hospital experience.

February 24, 2021

Interprofessional/interdisciplinary teamwork during the early COVID-19 pandemic: experience from a children's hospital within an academic health center.

August 12, 2020

Human factors and ergonomics to improve performance in intensive care units during the COVID-19 pandemic.

June 2, 2021

Inattentional blindness in anesthesiology: a gorilla is worth one thousand words.

November 24, 2021

Hospitalizations and deaths related to adverse drug events worldwide: systematic review of studies with national coverage.

May 25, 2022

Disparities after discharge: the association of limited English proficiency and postdischarge patient-reported issues.

December 8, 2021

The critical role of health information technology in the safe integration of behavioral health and primary care to improve patient care.

November 10, 2021

Improving medical residents’ self-assessment of their diagnostic accuracy: does feedback help?

February 2, 2022

Advancing diagnostic safety research: results of a systematic research priority setting exercise.

February 24, 2021

Maternal and neonatal health care worker well-being and patient safety climate amid the COVID-19 pandemic.

March 31, 2021

Understanding hazards for adverse drug events among older adults after hospital discharge: insights from frontline care professionals.

July 20, 2022

Medication errors at hospital admission and discharge: risk factors and impact of medication reconciliation process to improve healthcare.

October 20, 2021

Health care providers’ negative implicit attitudes and stereotypes of American Indians.

March 31, 2021

Radiologist errors by modality, anatomic region, and pathology for 1.6 million exams: what we have learned.

March 2, 2022

Diagnostic discrepancies between antemortem clinical diagnosis and autopsy findings in pediatric cancer patients.

September 22, 2021

Prevalence of potentially harmful multidrug interactions on medication lists of elderly ambulatory patients.

December 22, 2021

More than words: patients' views on apology and disclosure when things go wrong in cancer care.

August 24, 2011

March 16, 2022

Errors in adult trauma resuscitation: a systematic review.

June 30, 2021

Testimonial injustice: linguistic bias in the medical records of black patients and women.

June 6, 2021

Early warning scores to predict noncritical events overnight in hospitalized medical patients: a prospective case cohort study.

September 23, 2020

The calm before the storm: utilizing in situ simulation to evaluate for preparedness of an alternative care hospital during COVID-19 pandemic.

June 2, 2021

Recognition of adverse drug events in older hospitalized medical patients.

July 11, 2012

Guidance for health care leaders during the recovery stage of the COVID-19 pandemic: a consensus statement.

July 28, 2021

Patient harm during COVID-19 pandemic: using a human factors lens to promote patient and workforce safety.

December 23, 2020

Design of a safety dashboard for patients.

December 18, 2019

Direct oral anticoagulant-related medication incidents and pharmacists' interventions in hospital in-patients: evaluation using Reason's accident causation theory.

December 22, 2021

Prevalence and nature of medication errors and medication-related harm following discharge from hospital to community settings: a systematic review.

July 22, 2020

Patient voices in hospital safety during the COVID-19 pandemic.

November 2, 2022

May 26, 2021

Nurses' perceptions and demands regarding COVID-19 care delivery in critical care units and hospital emergency services.

December 2, 2020

Patient safety implications of wearing a face mask for prevention in the era of COVID-19 pandemic: a systematic review and consensus recommendations.

February 15, 2023

COVID-19 crisis, safe reopening of simulation centres and the new normal: food for thought.

August 19, 2020

State medical board regulation of compounding in physician offices.

June 9, 2021

Potentially inappropriate medications and their effect on falls during hospital admission.

March 23, 2022

Diagnostic delays among COVID-19 patients with a second concurrent diagnosis.

February 22, 2023

Barriers to and facilitators of bedside nursing handover: a systematic review and meta-synthesis.

July 7, 2021

The burden of opioid-related adverse drug events on hospitalized previously opioid-free surgical patients.

March 10, 2021

Learning during crisis: the impact of COVID-19 on hospital-acquired pressure injury incidence.

June 2, 2021

Telemedicine as a medical examination tool during the Covid-19 emergency: the experience of the onco-haematology center of Tor Vergata Hospital in Rome.

December 23, 2020

Bracing for the storm: one health care system's planning for the COVID-19 surge.

November 11, 2020

How to scale up quality and safety program with the home care accreditation.

April 13, 2022

Assessing the impact of virtual medication history technicians on medication reconciliation discrepancies.

December 1, 2021

Do falls and other safety issues occur more often during handovers when nurses are away from patients? Findings from a retrospective study design.

November 11, 2020

Development of a core drug list towards improving prescribing education and reducing errors in the UK.

March 2, 2011

Critical care simulation education program during the COVID-19 pandemic.

November 10, 2021

Incidence of nosocomial COVID-19 in patients hospitalized at a large US academic medical center.

October 21, 2020

Nursing strategies to safeguard COVID-19 patients from harm in the intensive care unit.

December 8, 2021

Thematic analysis of nurses' experiences with The Joint Commission's medication management titration standards.

September 15, 2021

Measuring and improving diagnostic safety in primary care: addressing the “twin” pandemics of diagnostic error and clinician burnout.

March 3, 2021

Assessment of requests for medication-related follow-up after hospital discharge, and the relation to unplanned hospital revisits, in older patients: a multicentre retrospective chart review.

December 8, 2021

Recommendations for the safety of hospitalised patients in the context of the COVID-19 pandemic: a scoping review.

October 5, 2022

NHS ‘Learning from Deaths’ reports: a qualitative and quantitative document analysis of the first year of a countrywide patient safety programme.

July 21, 2021

Characteristics and unexpected COVID-19 diagnoses in resuscitation room patients during the COVID-19 outbreak - a retrospective case series.

September 30, 2020

The impact of the built environment on patient falls in hospital rooms: an integrative review.

June 16, 2021

Improving discharge safety in a pediatric emergency department.

October 26, 2022

Allergic adverse drug events after alert overrides in hospitalized patients.

September 21, 2022

Predictors of serious opioid-related adverse drug events in hospitalized patients.

July 8, 2020

Clinical diagnoses vs. autopsy findings in early deceased septic patients in the intensive care: a retrospective cohort study.

July 28, 2021

Performance of a trigger tool for detecting drug-related hospital admissions in older people: analysis from the OPERAM trial.

February 16, 2022

Exploring changes in patient safety incidents during the COVID-19 pandemic in a Canadian regional hospital system: a retrospective time series analysis.

February 23, 2022

AI for radiographic COVID-19 detection selects shortcuts over signal.

June 16, 2021

Why test results are still getting "lost" to follow-up: a qualitative study of implementation gaps.

May 12, 2021

SEIPS 2.0: a human factors framework for studying and improving the work of healthcare professionals and patients.

October 3, 2013

Determinants of burnout and other aspects of psychological well-being in healthcare workers during the Covid-19 pandemic: a multinational cross-sectional study.

May 5, 2021

Speaking up during the COVID-19 pandemic: nurses' experiences of organizational disregard and silence.

February 1, 2023

Related Resources

Organisational conditions for safety management practice in homecare and nursing homes, pre-pandemic and in pandemic.

March 27, 2024

Identifying adverse events in patients hospitalized in isolation or quarantine due to COVID-19.

May 10, 2023

Patient Safety Innovations

Enhancing Support for Patients’ Social Needs to Reduce Hospital Readmissions and Improve Health Outcomes

March 29, 2023

Medication errors: the year in review: January through December 2021.

January 11, 2023

Detectability of medication errors with a STOPP/START-based medication review in older people prior to a potentially preventable drug-related hospital admission.

December 21, 2022

Experience of hospital-initiated medication changes in older people with multimorbidity: a multicentre mixed-methods study embedded in the OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM) trial.

December 7, 2022

Golden State Medical Supply, Inc. Issues a Voluntary Nationwide Recall of Atenolol 25 mg Tablets and Clopidogrel 75 mg Tablets Due to a Label Mix-up.

October 19, 2022

COVID-19 in Nursing Homes: CMS Needs to Continue to Strengthen Oversight of Infection Prevention and Control.

October 12, 2022

Pharmacy leadership amid the pandemic: maintaining patient safety during uncertain times.

September 14, 2022

Racial and ethnic discrepancy in pulse oximetry and delayed identification of treatment eligibility among patients with COVID-19.

June 22, 2022

Missed nursing care in the critical care unit, before and during the COVID-19 pandemic: a comparative cross-sectional study.

June 22, 2022

Risk from delayed or missed care and non-COVID-19 outcomes for older patients with chronic conditions during the pandemic.

June 8, 2022

What is needed to sustain improvements in hospital practices post-COVID-19? A qualitative study of interprofessional dissonance in hospital infection prevention and control.

May 4, 2022

Improving the specificity of drug-drug interaction alerts: can it be done?

April 6, 2022

Prescribing errors in post-COVID-19 patients: prevalence, severity, and risk factors in patients visiting a post-COVID-19 outpatient clinic.

March 23, 2022

Sources of medication omissions among hospitalized older adults with polypharmacy.

March 9, 2022

Patient Safety Primers

Coronavirus Disease 2019 (COVID-19) and Safety of Older Adults Residing in Nursing Homes

February 24, 2022

Clinical reasoning in dire times- analysis of cognitive biases in clinical cases during the COVID-19 pandemic.

February 23, 2022

Coronavirus disease 2019 (COVID-19) pandemic, central-line-associated bloodstream infection (CLABSI), and catheter-associated urinary tract infection (CAUTI): the urgent need to refocus on hardwiring prevention efforts.

February 7, 2022

Supervision, interprofessional collaboration, and patient safety in intensive care units during the COVID-19 pandemic.

November 10, 2021

Transmission of community- and hospital-acquired SARS-CoV-2 in hospital settings in the UK: a cohort study.

November 10, 2021

Medication errors at hospital admission and discharge: risk factors and impact of medication reconciliation process to improve healthcare.

October 20, 2021

Impact of clinical decision support therapeutic interchanges on hospital discharge medication omissions and duplications.

October 20, 2021

Role of nursing home quality on COVID-19 cases and deaths: evidence from Florida nursing homes.

September 22, 2021

Patient safety and ethical implications of healthcare sick leave policies in the pandemic era.

September 15, 2021

Effect of medication reconciliation on patient reported potential adverse events after hospital discharge.

September 8, 2021

Challenges and potential solutions for patient safety in an infectious-agent-isolation environment: a study of 484 COVID-19-related event reports across 94 hospitals

September 1, 2021

Patient factors and hospital outcomes associated with atypical presentation in hospitalized older adults with COVID-19 during the first surge of the pandemic.

August 18, 2021

Patient-safety incidents during COVID-19 health crisis in France: An exploratory sequential multi-method study in primary care.

July 21, 2021

See More About The Topic

Hospital Pharmacists

Hospitals

Health Care Providers

Health Care Executives and Administrators

Geriatrics

Drug-drug interactions and prescription appropriateness at hospital discharge: experience with COVID-19 patients.

Enhancing Support for Patients’ Social Needs to Reduce Hospital Readmissions and Improve Health Outcomes

Coronavirus Disease 2019 (COVID-19) and Safety of Older Adults Residing in Nursing Homes

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

Drug-drug interactions and prescription appropriateness at hospital discharge: experience with COVID-19 patients.

Enhancing Support for Patients’ Social Needs to Reduce Hospital Readmissions and Improve Health Outcomes

Coronavirus Disease 2019 (COVID-19) and Safety of Older Adults Residing in Nursing Homes

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

Submit Your Innovations

Continue as a Guest

Continue Logged In

Submit Your Innovations

Continue as a Guest

Continue logged in

New Users to the PSNet site