The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial.
Bakker T, Klopotowska JE, Dongelmans DA, et al. The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial. Lancet. 2024;403(10425):439-449. doi:10.1016/s0140-6736(23)02465-0.
Alert fatigue occurs when clinical decision support systems (CDSS) produce numerous low-relevance alerts, leading to high override rates and the risk of missing relevant alerts. In this study, alerts for high-risk drug-drug interactions (DDI) were tailored to the intensive care unit. The tailored alerts led to a 12% decrease in high-risk DDI administrations.