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Estimation of breast cancer overdiagnosis in a U.S. breast screening cohort.

Ryser MD, Lange J, Inoue LYT, et al. Estimation of breast cancer overdiagnosis in a U.S. breast screening cohort. Ann Intern Med. Epub 2022 Mar 1. doi: 10.7326/M21-3577.

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March 16, 2022
Ryser MD, Lange J, Inoue LYT, et al. Ann Intern Med. 2022;175(4):471-478.

Overdiagnosis of breast cancer can result in overtreatment and cause physical and emotional harm. Based on data from 35,986 women in a US-based breast cancer screening registry, this study estimates that15.4% of screen-detected cancers are overdiagnosed (i.e., detecting indolent preclinical cancer or detecting progressive preclinical cancer among women who would have died of unrelated causes before clinical diagnosis), which is higher than previous estimates. The authors suggest that data can improve shared decision-making between patients and physicians.

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Ryser MD, Lange J, Inoue LYT, et al. Estimation of breast cancer overdiagnosis in a U.S. breast screening cohort. Ann Intern Med. Epub 2022 Mar 1. doi: 10.7326/M21-3577.