The COVID-19 pandemic has raised concerns about home healthcare, which is common among older and disabled patients managing chronic conditions. This qualitative study explored perceived successes and challenges with regards to infection prevention and control among home healthcare staff. Identified challenges included the unpredictability of the home environment, patient/family dynamics, the intermittent nature of home healthcare, and staffing issues. In the midst of the COVID-19 pandemic, home health leadership should consider these challenges as they prioritize infection prevention and control.