Resident work hours, fatigue, and discontinuity in care continue to be significant areas of concern in patient safety. This study surveyed inpatients from three different types of institutions to highlight the knowledge, concerns, and attitudes expressed by patients around these issues. Investigators were surprised to learn that the majority of patients were in fact not concerned about either fatigue or discontinuity despite media attention given to these topics. However, trust in physicians and satisfaction were related to the degree of concern about fatigue and discontinuity. Such perceptions among patients may be important in guiding future efforts to ensure patient-centered care.