Standardized handoff tools can reduce adverse events among hospitalized patients. This retrospective cohort study found that the I-PASS handoff tool’s illness severity assessment can identify patients at higher risk of overnight clinical deterioration and rapid response team (RRT) activation. Patients who were flagged as being at risk for higher levels of care or whose illness trajectory was uncertain were significantly more likely to have an overnight RRT activation compared with stable patients. The authors suggest that this approach can help overnight residents prioritize patient care.