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Impact of sample size on variation of adverse events and preventable adverse events: systematic review on epidemiology and contributing factors.
January 5, 2011
Lessing C, Schmitz A, Albers B, et al. Qual Saf Health Care. 2010;19(6):e24.
This systematic review of more than 150 studies on the incidence of adverse events found considerable variation in the estimated frequency of adverse events across studies. In general, smaller studies (sample size less than 1000 patients) found a much higher incidence of errors, which may have been related to the methods used to detect errors.
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