This observational study enrolled 2,576 women undergoing cesarean delivery at a single tertiary care hospital over a five-year period to evaluate the impact of an evidence-based bundle on surgical site infections. The comprehensive and multidisciplinary bundle included preoperative, intraoperative and postoperative actions. Implementation of the bundle resulted in a 60% reduction in the risk of surgical site infections, from 1.5% in the preintervention period to 0.56% after implementation.