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Inappropriate dosing of direct oral anticoagulants in patients with atrial fibrillation.

Sugrue A, Sanborn D, Amin M, et al. Inappropriate dosing of direct oral anticoagulants in patients with atrial fibrillation. Am J Cardiol. 2021;144:52-59. doi: 10.1016/j.amjcard.2020.12.062.

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April 28, 2021
Sugrue A, Sanborn D, Amin M, et al. Am J Cardiol. 2020;144:52-59.

Anticoagulants are common medications that carry the potential for serious harm if administered incorrectly. This retrospective review of 8,576 patients with atrial fibrillation who received direct oral anticoagulants identified inappropriate dosing in nearly 15% of cases, with most patients receiving an inappropriately low dose. Over one year of follow-up, the authors did not identify any significant difference in the incidence of stroke, embolism, bleeding, or ischemic attacks between patients who were inappropriately, versus appropriately, dosed.

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Sugrue A, Sanborn D, Amin M, et al. Inappropriate dosing of direct oral anticoagulants in patients with atrial fibrillation. Am J Cardiol. 2021;144:52-59. doi: 10.1016/j.amjcard.2020.12.062.