Hospital-physician integration provides physicians with opportunities to be engaged in organizational management and to influence organizational culture. Using data (including from the Hospital Survey on Patient Safety Culture™ [SOPS®]), this cross-sectional study explores the impact of hospital-physician integration on patient safety culture. Study findings suggest a significant positive relationship between higher levels of physician integration and perceptions of hospital management support for patient safety. Findings did not identify a significant correlation with communication openness or organizational learning. These findings highlight the need for future research on integration and patient safety as more physicians take on management roles.