The authors reviewed emerging workplace recommendations for reducing workers’ exposures to COVID-19 and, using human factors and ergonomic principles, proposed an approach for supporting worker safety, health and well-being during the pandemic. The recommended approach includes six key characteristics: (1) leadership commitment; (2) policies, programs and practices fostering supportive working conditions; (3) stakeholder participation at every level of the organization; (4) comprehensive and collaborative strategies; (5) adherence to state and federal regulations, as well as ethical norms, and; (6) commitment to data-driven change and continuous improvement.