The Regional Medication Safety Program for Hospitals (RMSPH) implemented a program in 2001 to coordinate the activities of 65 Philadelphia-area hospitals to improve their medication safety administration. The work focused on 16 key improvement areas defined through a collaborative process involving the Health Care Improvement Foundation (HCIF), an affiliate of the Delaware Valley Healthcare Council (DVHC), along with ECRI and the Institute for Safety Medication Practices (ISMP). Tools were developed and disseminated to support improvement efforts at participating hospitals. The report outlines the results of the work and reviews the aggregate data compared to baseline numbers collected in June 2004.