This article briefly summarizes a multicenter retrospective cross-sectional analysis of 44 clinical trials conducted from 2009-2019 in the United Arab Emirates to assess the degree to which the trials optimized patient safety and care coordination. Clinical trial materials generally contained safety-related information but trial participants were not advised to inform their primary care doctors about trial participation and trials did not routinely use hospital information systems to communicate with physicians about patient participation in clinical trials. This lack of care coordination between clinical trial and healthcare settings should be targeted to improve patient safety.