Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial.

Manuel R Blum; B. Sallevelt; Anne Spinewine; Denis O’Mahony; Elisavet Moutzouri; Martin Feller; Christine Baumgartner; Marie Roumet; Katharina Tabea Jungo; Nathalie Schwab; Lisa Bretagne; Shanthi Beglinger; Carole E Aubert; Ingeborg Wilting; Stefanie Thevelin; Kevin Murphy; Corlina J A Huibers; A Clara Drenth-van Maanen; Benoit Boland; Erin Crowley; Anne Eichenberger; Michiel Meulendijk; Emma Jennings; Luise Adam; Marvin J Roos; Laura Gleeson; Zhengru Shen; Sophie Marien; Arend-Jan Meinders; Oliver Baretella; Seraina Netzer; Maria de Montmollin; Anne Fournier; Ariane Mouzon; Cian O’Mahony; Drahomir Aujesky; Dimitris Mavridis; Stephen Byrne; Paul A F Jansen; Matthias Schwenkglenks; Marco Spruit; Olivia Dalleur; Wilma Knol; Sven Trelle; Nicolas Rodondi

Study

Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial.

August 18, 2021

Blum MR, Sallevelt B, Spinewine A, et al. BMJ. 2021;374:n1585.

View more articles from the same authors.

Older adults with multimorbidity and polypharmacy are at increased risk of adverse drug events. This cluster randomized controlled trial compared drug-related hospitalization rates of older adults who received a structured deprescribing intervention and those who received usual care. While rates of polypharmacy decreased, there was no effect on drug-related hospitalizations.

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Overtreatment

Clinical Pharmacist Involvement

Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial.

Deprescribing as a Patient Safety Strategy

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