Telehealth and remote patient care are increasingly used in many clinical settings. Informed by Safety I and Safety II frameworks, this multi-method study used both a retrospective analysis of patient safety incidents and prospective ethnographic observation and interviews to identify the individual, organizational, and systems-level factors contributing to or mitigating safety and near-miss incidents in remote primary care in the United Kingdom. The authors note that certain patient populations (e.g., those with complex comorbidities, with vague or generalized symptoms, cardiac or abdominal emergencies) may be particularly vulnerable to diagnostic errors or delays in care.