Potentially inappropriate prescribing and its associations with health-related and system-related outcomes in hospitalised older adults: a systematic review and meta-analysis.

Alemayehu B. Mekonnen; Bernice Redley; Barbora Courten; Elizabeth Manias

Review

Potentially inappropriate prescribing and its associations with health-related and system-related outcomes in hospitalised older adults: a systematic review and meta-analysis.

January 19, 2022

Mekonnen AB, Redley B, Courten B, et al. Br J Clin Pharmacol. 2021;87(11):4150-4172.

View more articles from the same authors.

Potentially inappropriate prescribing in older adults can result in medication-related harm. This systematic review of 63 studies found that potentially inappropriate prescribing was significantly associated with several system-related and health-related outcomes for older adults, including adverse drug events and functional decline; however, the study did not identify significant associations with all-cause mortality or hospital readmission.

PubMed citation

Free full text

Related Resources From the Same Author(s)

Nurses' harm prevention practices during admission of an older person to the hospital: a multi-method qualitative study.

August 10, 2022

Safer prescribing for hospitalized older adults with an electronic health records‐based prescribing context.

October 28, 2020

Do final-year medical students have sufficient prescribing competencies? A systematic literature review.

February 14, 2018

Barriers and enablers to nurses' use of harm prevention strategies for older patients in hospital: a cross-sectional survey.

May 11, 2022

An e-Delphi study to obtain expert consensus on the level of risk associated with preventable e-prescribing events.

April 13, 2022

Impact of a nationwide prospective drug utilization review program to improve prescribing safety of potentially inappropriate medications in older adults: an interrupted time series with segmented regression analysis.

November 4, 2020

Potentially inappropriate prescribing for adults living with diabetes mellitus: a scoping review.

October 5, 2022

Prevalence, contributory factors and severity of medication errors associated with direct-acting oral anticoagulants in adult patients: a systematic review and meta-analysis.

January 12, 2022

Deprescribing for community-dwelling older adults: a systematic review and meta-analysis.

September 16, 2020

Nursing guidelines for comprehensive harm prevention strategies for adult patients in acute hospitals: an integrative review and synthesis.

February 23, 2022

The nature, severity and causes of medication incidents from an Australian community pharmacy incident reporting system: the QUMwatch study.

July 28, 2021

Potentially inappropriate prescribing in older people with dementia in care homes: a retrospective analysis.

February 15, 2012

Patient and physician perspectives of deprescribing potentially inappropriate medications in older adults with a history of falls: a qualitative study.

May 5, 2021

Prevalence of potentially inappropriate medication use in older adults living in nursing homes: a systematic review.

August 17, 2016

STOPP/START criteria for potentially inappropriate medications/potential prescribing omissions in older people: origin and progress.

January 8, 2020

Development of a core drug list towards improving prescribing education and reducing errors in the UK.

March 2, 2011

Modification of potentially inappropriate prescribing following fall-related hospitalizations in older adults.

July 10, 2019

Which adverse events and which drugs are implicated in drug-related hospital admissions? A systematic review and meta-analysis.

March 22, 2023

Associations of physician burnout with career engagement and quality of patient care: systematic review and meta-analysis.

September 28, 2022

Association of intraoperative anaesthesia handovers with patient morbidity and mortality: a systematic review and meta-analysis.

November 4, 2020

Functional decline associated with polypharmacy and potentially inappropriate medications in community-dwelling older adults with dementia.

February 22, 2012

Do patient engagement interventions work for all patients? A systematic review and realist synthesis of interventions to enhance patient safety.

September 15, 2021

Patient factors associated with new prescribing of potentially inappropriate medications in multimorbid US older adults using multiple medications.

May 12, 2021

Using health information technology in residential aged care homes: an integrative review to identify service and quality outcomes.

August 17, 2022

March 16, 2022

Associations of person-related, environment-related and communication-related factors on medication errors in public and private hospitals: a retrospective clinical audit.

November 17, 2021

Electronic prescribing and other forms of technology to reduce inappropriate medication use and polypharmacy in older people: a review of current evidence.

July 18, 2012

February 2, 2022

Associations of physicians’ prescribing experience, work hours, and workload with prescription errors.

November 18, 2020

Associations of workflow disruptions in the operating room with surgical outcomes: a systematic review and narrative synthesis.

June 17, 2020

Detectability of medication errors with a STOPP/START-based medication review in older people prior to a potentially preventable drug-related hospital admission.

December 21, 2022

Potentially inappropriate medication administration is associated with adverse postoperative outcomes in older surgical patients: a retrospective cohort study.

September 14, 2022

Resident duty hours and resident and patient outcomes: systematic review and meta-analysis.

November 16, 2022

Incidence and variables associated with inconsistencies in opioid prescribing at hospital discharge and its associated adverse drug outcomes.

May 5, 2021

Hospitalizations and deaths related to adverse drug events worldwide: systematic review of studies with national coverage.

May 25, 2022

Outcomes and patient safety in overlapping vs. nonoverlapping total joint arthroplasty: a systematic review and meta-analysis.

January 19, 2022

Outcomes of medication misadventure among people with cognitive impairment or dementia: a systematic review and meta-analysis.

July 21, 2021

Implicit racial/ethnic bias among health care professionals and its influence on health care outcomes: a systematic review.

October 16, 2015

How would final-year medical students perform if their skill-based prescription assessment was real life?

February 22, 2023

Cost of adverse drug events related to potentially inappropriate medication use: a systematic review.

June 15, 2022

Impact of pharmacist interventions on medication errors in hospitalized pediatric patients: a systematic review and meta-analysis.

October 14, 2020

American Geriatrics Society 2019 Updated AGS Beers Criteria for Potentially Inappropriate Medication Use in Older Adults.

June 12, 2019

Potentially inappropriate medication combination with opioids among older dental patients: a retrospective review of insurance claims data.

October 7, 2020

Are operating room distractions, interruptions, and disruptions associated with performance and patient safety? A systematic review and meta-analysis.

May 19, 2021

August 19, 2020

The association between health care staff engagement and patient safety outcomes: a systematic review and meta-analysis.

February 3, 2021

Root cause analysis using the prevention and recovery information system for monitoring and analysis method in healthcare facilities: a systematic literature review.

June 8, 2022

Weekend effect on in-hospital mortality for ischemic and hemorrhagic stroke in US rural and urban hospitals.

November 18, 2020

Patient factors and hospital outcomes associated with atypical presentation in hospitalized older adults with COVID-19 during the first surge of the pandemic.

August 18, 2021

Automated capture of intraoperative adverse events using artificial intelligence: a systematic review and meta-analysis.

March 15, 2023

Rate of preventable mortality in hospitalized patients: a systematic review and meta-analysis.

April 1, 2020

Clinical and economic impacts of explicit tools detecting prescribing errors: a systematic review.

May 26, 2021

Self-reported gaps in care coordination and preventable adverse outcomes among older adults receiving home health care.

January 18, 2023

Impact of computerised physician order entry (CPOE) on the incidence of chemotherapy-related medication errors: a systematic review.

April 7, 2021

Impact of the WHO Surgical Safety Checklist relative to its design and intended use: a systematic review and meta-meta-analysis.

November 24, 2021

Individualized medication review in older people with multimorbidity: a comparative analysis between patients living at home and in a nursing home.

May 25, 2022

Nursing interventions to reduce medication errors in paediatrics and neonates: systematic review and meta-analysis.

December 8, 2021

Systematic review and meta-analysis of interventions for operating room to intensive care unit handoffs.

March 10, 2021

How satisfied are patients and surgeons with telemedicine in orthopaedic care during the COVID-19 pandemic? A systematic review and meta-analysis.

February 10, 2021

Engaging with ethnic minority consumers to improve safety in cancer services: a national stakeholder analysis.

May 25, 2022

The impact of health care strikes on patient mortality: a systematic review and meta-analysis of observational studies.

November 30, 2022

Tipping the balance: a systematic review and meta-ethnography to unfold the complexity of surgical antimicrobial prescribing behavior in hospital settings.

August 10, 2022

Surgeon burnout, impact on patient safety and professionalism: a systematic review and meta-analysis.

March 16, 2022

Factors associated with potentially harmful medication prescribing in nursing homes: a scoping review.

September 28, 2022

Evaluation of clinical practice guidelines on fall prevention and management for older adults: a systematic review.

January 12, 2022

Preventable medication harm across health care settings: a systematic review and meta-analysis.

February 17, 2021

Performance of 3 sets of criteria for potentially inappropriate prescribing in older people to identify inadequate drug treatment.

December 14, 2022

What is the evidence that a pharmacy team working in an acute or emergency medicine department improves outcomes for patients: a systematic review.

November 2, 2022

Factors associated with potentially missed acute deterioration in primary care: cohort study of UK general practices.

October 20, 2021

Diagnostic errors in the intensive care unit: a systematic review of autopsy studies.

August 8, 2012

How effective are electronic medication systems in reducing medication error rates and associated harm among hospital inpatients? A systematic review and meta-analysis.

December 2, 2020

Evolving factors in hospital safety: a systematic review and meta-analysis of hospital adverse events.

September 29, 2021

Worldwide incidence of surgical site infections in general surgical patients: a systematic review and meta-analysis of 488,594 patients.

December 8, 2021

The safety of health care for ethnic minority patients: a systematic review.

July 29, 2020

Resident and family engagement in medication management in aged care facilities: a systematic review.

July 7, 2021

Family involvement in managing medications of older patients across transitions of care: a systematic review.

June 26, 2019

Pharmacist-led intervention on the reduction of inappropriate medication use in patients with heart failure: a systematic review of randomized trials and non-randomized intervention studies.

August 18, 2021

Prevalence, causes and severity of medication administration errors in the neonatal intensive care unit: a systematic review and meta-analysis.

December 14, 2022

Systems approach to health service design, delivery and improvement: a systematic review and meta-analysis.

February 3, 2021

Barriers and facilitators to patient engagement in patient safety from patients and healthcare professionals' perspectives: a systematic review and meta-synthesis.

August 25, 2021

Impact of medication reviews on potentially inappropriate medications and associated costs among older women in aged care.

September 21, 2022

Impact of pharmacist interventions provided in the emergency department on quality use of medicines: a systematic review and meta-analysis.

March 8, 2023

Clinical deterioration and hospital‐acquired complications in adult patients with isolation precautions for infection control: a systematic review.

October 14, 2020

Relationships between comprehensive characteristics of nurse work schedules and adverse patient outcomes: a systematic literature review.

March 24, 2021

Variation in detected adverse events using trigger tools: a systematic review and meta-analysis.

September 21, 2022

Key potentially inappropriate drugs in pediatrics: the KIDs list.

June 24, 2020

Adverse events associated with patient isolation: a systematic literature review and meta-analysis.

January 19, 2022

The scientific literature on Coronaviruses, COVID-19 and its associated safety-related research dimensions: a scientometric analysis and scoping review.

July 15, 2020

Impact of remote consultations on antibiotic prescribing in primary healthcare: systematic review.

December 2, 2020

The MedSafer study-electronic decision support for deprescribing in hospitalized older adults: a cluster randomized clinical trial.

February 2, 2022

Adverse events during intrahospital transport of critically ill patients: a systematic review and meta-analysis.

February 9, 2022

The association between nurse staffing and omissions in nursing care: a systematic review.

July 11, 2018

Effects of rapid response systems on clinical outcomes: systematic review and meta-analysis.

January 2, 2008

A mixed-methods analysis of patient safety incidents involving opioid substitution treatment with methadone or buprenorphine in community-based care in England and Wales.

November 11, 2020

Medication errors' causes analysis in home care setting: a systematic review.

February 9, 2022

The views and experiences of patients and health-care professionals on the disclosure of adverse events: a systematic review and qualitative meta-ethnographic synthesis.

April 8, 2020

Effectiveness of pharmacist intervention to reduce medication errors and health-care resources utilization after transitions of care: a meta-analysis of randomized controlled trials.

July 19, 2017

Rate of sepsis hospitalizations after misdiagnosis in adult emergency department patients: a look-forward analysis with administrative claims data using Symptom-Disease Pair Analysis of Diagnostic Error methodology in an integrated health system.

May 12, 2021

Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial.

August 18, 2021

Older patients' engagement in hospital medication safety behaviours.

June 16, 2021

Related Resources

Prevention of adverse drug events in hospitals.

March 21, 2024

Electronic medication reconciliation tools aimed at healthcare professionals to support medication reconciliation: a systematic review.

February 28, 2024

Post-implementation optimization of medication alerts in hospital computerized provider order entry systems: a scoping review.

December 6, 2023

Intervention of pharmacist included in multidisciplinary team to reduce adverse drug event: a qualitative systematic review.

November 1, 2023

Pharmacy-led medication reconciliation is best practice.

October 11, 2023

A virtual breakthrough series collaborative to support deprescribing interventions across Veterans Affairs healthcare settings.

October 4, 2023

Impact of pharmacist-led admission medication reconciliation on patient outcomes in a large health system.

September 20, 2023

Handling polypharmacy--a qualitative study using focus group interviews with older patients, their relatives, and healthcare professionals.

September 13, 2023

Exploring the impact of safety culture on incident reporting: lessons learned from machine learning analysis of NHS England staff survey and incident data.

August 30, 2023

Incidence and severity of medication reconciliation discrepancies in trauma patients.

August 16, 2023

Uptake of pharmacist recommendations by patients after discharge: implementation study of a patient-centered medicines review service.

May 3, 2023

Detectability of medication errors with a STOPP/START-based medication review in older people prior to a potentially preventable drug-related hospital admission.

December 21, 2022

Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) - a randomized controlled trial.

November 30, 2022

Criteria for the selection of paediatric patients susceptible to reconciliation error.

November 16, 2022

Correlation between the number of patient-reported adverse events, adverse drug events, and quality of life in older patients: an observational study.

November 2, 2022

What is the evidence that a pharmacy team working in an acute or emergency medicine department improves outcomes for patients: a systematic review.

November 2, 2022

Impact of medication reviews on potentially inappropriate medications and associated costs among older women in aged care.

September 21, 2022

Frailty and potentially inappropriate prescribing in older people with polypharmacy: a bi-directional relationship?

August 31, 2022

The effect of structured medication review followed by face-to-face feedback to prescribers on adverse drug events recognition and prevention in older inpatients - a multicenter interrupted time series study.

August 10, 2022

WebM&M Cases

Challenges of Diabetes Management and Medication Reconciliation

August 5, 2022

Differences in medication reconciliation interventions between six hospitals: a mixed method study.

June 29, 2022

Cost of adverse drug events related to potentially inappropriate medication use: a systematic review.

June 15, 2022

What is the medication iatrogenic risk in elderly outpatients for chronic pain?

June 1, 2022

Individualized medication review in older people with multimorbidity: a comparative analysis between patients living at home and in a nursing home.

May 25, 2022

May 4, 2022

Standardized assessment of medication reconciliation in post-acute care.

April 27, 2022

The effect of a transitional pharmaceutical care program on the occurrence of ADEs after discharge from hospital in patients with polypharmacy.

April 27, 2022

Medication discrepancy rates and sources upon nursing home intake: a prospective study.

April 6, 2022

Sources of medication omissions among hospitalized older adults with polypharmacy.

March 9, 2022

Risk factors for clinically relevant deviations in patients' medication lists reported by patients in personal health records: a prospective cohort study in a hospital setting.

March 2, 2022

See More About The Topic

Hospitals

Geriatrics

Hospital Pharmacy

Medication Errors/Preventable Adverse Drug Events

Ordering/Prescribing Errors

Potentially inappropriate prescribing and its associations with health-related and system-related outcomes in hospitalised older adults: a systematic review and meta-analysis.

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

Potentially inappropriate prescribing and its associations with health-related and system-related outcomes in hospitalised older adults: a systematic review and meta-analysis.

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

Submit Your Innovations

Continue as a Guest

Continue Logged In

Submit Your Innovations

Continue as a Guest

Continue logged in

New Users to the PSNet site