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PSNet: Patient Safety Network
Journal Article
Study

Predictors of serious opioid-related adverse drug events in hospitalized patients.

Minhaj FS, Rappaport SH, Foster J, et al. J Patient Saf. 2020;Epub Jun 6.

Opioids are known to be high-risk medications, and their misuse is an increasingly recognized patient safety problem. This retrospective case-control study of inpatients being administered at least one opioid dose sought to identify risk factors predisposing inpatients to opioid-related adverse drug events (ADEs) requiring the use of naloxone. Patients 65 years of age or older, female, receiving orthopedic surgery, certain comorbid conditions, or receiving patient-controlled analgesia were more likely to require naloxone.