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Prescription opioid dose reductions and potential adverse events: a multi-site observational cohort study in diverse US health systems.

Metz VE, Ray GT, Palzes V, et al. Prescription opioid dose reductions and potential adverse events: a multi-site observational cohort study in diverse US health systems. J Gen Intern Med. 2023;Epub Nov 6. doi:10.1007/s11606-023-08459-y.

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November 29, 2023
Metz VE, Ray GT, Palzes V, et al. J Gen Intern Med. 2023;Epub Nov 6.
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In response to the increasing opioid crisis, many medical associations, policy makers, and insurers have argued for dose reductions. However, when doses are reduced too quickly, patients may experience short- and long-term adverse events. Consistent with other studies, dose reductions higher than 30% were associated with higher odds of emergency department visits, opioid overdose, and all-cause mortality in the month following dose reduction.

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Metz VE, Ray GT, Palzes V, et al. Prescription opioid dose reductions and potential adverse events: a multi-site observational cohort study in diverse US health systems. J Gen Intern Med. 2023;Epub Nov 6. doi:10.1007/s11606-023-08459-y.

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