Preventing potential patient harm through clinical content interventions during oncology clinical trial implementation.

Vivian C Loo; Sarah Kim; Lisa M Johnson; Howard Kay; Annie Yi; Jason Chen; Lisa O Asmar-Abdien

Study

Preventing potential patient harm through clinical content interventions during oncology clinical trial implementation.

September 20, 2023

Loo VC, Kim S, Johnson LM, et al. J Patient Saf. 2023;19(7):460-464.

View more articles from the same authors.

Ensuring the safety of clinical trial participants is paramount to successful, meaningful clinical research. In this study, researchers examined 585 clinical trial documents and found that 17% included potential patient safety interventions (e.g., resolving medication dosing discrepancies). The authors suggest that clinical specialists’ review of study protocol documents could enhance patient safety during clinical trial conduct.

PubMed citation

Free full text

Related Resources From the Same Author(s)

Standardized assessment of medication reconciliation in post-acute care.

April 27, 2022

Seroprevalence of SARS-CoV-2 among frontline health care personnel in a multistate hospital network--13 academic medical centers, April-June 2020.

September 23, 2020

Association of diagnostic stewardship for blood cultures in critically ill children with culture rates, antibiotic use, and patient outcomes: results of the Bright STAR Collaborative.

May 18, 2022

Bracing for the storm: one health care system's planning for the COVID-19 surge.

November 11, 2020

The intended and unintended consequences of communication systems on general internal medicine inpatient care delivery: a prospective observational case study of five teaching hospitals.

February 13, 2013

Drug-drug interactions and actual harm to hospitalized patients: a multicentre study examining the prevalence pre- and post-electronic medication system implementation.

April 10, 2024

Problems after discharge and understanding of communication with their primary care physicians (PCPs) among hospitalized seniors: a mixed methods study.

September 22, 2010

Prospective evaluation of a multifaceted intervention to improve outcomes in intensive care: the Promoting Respect and Ongoing Safety through Patient Engagement Communication and Technology study.

May 24, 2017

Use of a structured approach and virtual simulation practice to improve diagnostic reasoning.

February 23, 2022

Ethical considerations and patient safety concerns for cancelling non-urgent surgeries during the COVID-19 pandemic: a review.

May 12, 2021

Optimizing Pediatric Patient Safety in the Emergency Care Setting.

October 19, 2022

The 2017 ACGME common work hour standards: promoting physician learning and professional development in a safe, humane environment.

January 31, 2018

Patterns of opioid administration among opioid-naive inpatients and associations with postdischarge opioid use: a cohort study.

July 10, 2019

Recommendations to improve the usability of drug–drug interaction clinical decision support alerts.

November 25, 2015

Development of prescribing indicators related to opioid-related harm in patients with chronic pain in primary care- a modified e-Delphi study.

January 17, 2024

A model for the departmental quality management infrastructure within an academic health system.

September 28, 2016

Changes in medical errors after implementation of a handoff program.

November 12, 2014

Association of implementation and social network factors with patient safety culture in medical homes: a coincidence analysis.

September 2, 2020

Challenges and strategies for patient safety in primary care: a qualitative study.

September 28, 2022

Association between unmet nonmedication needs after hospital discharge and readmission or death among acute respiratory failure survivors: a multicenter prospective cohort study.

February 15, 2023

Discontinuation of antihyperglycemic therapy after acute myocardial infarction: medical necessity or medical error?

September 5, 2012

Implementing standardized reporting and safety checklists.

June 1, 2011

Pharmacy e-prescription dispensing before and after CancelRx implementation.

September 20, 2023

Primary care pediatricians' interest in diagnostic error reduction.

July 20, 2016

Pediatric trainees' speaking up about unprofessional behavior and traditional patient safety threats.

September 30, 2020

The frequency of intravenous medication administration errors related to smart infusion pumps: a multihospital observational study.

March 16, 2016

Effect of an emergency department process improvement package on suicide prevention: the ED-SAFE 2 cluster randomized clinical trial.

May 31, 2023

Overrides of medication-related clinical decision support alerts in outpatients.

January 8, 2014

Implementing the clinical occurrence reporting and learning system: a double-loop learning incident reporting system in long-term care.

March 24, 2021

Effect of genetic diagnosis on patients with previously undiagnosed disease.

November 7, 2018

When order sets do not align with clinician workflow: assessing practice patterns in the electronic health record.

June 19, 2019

Extended work shifts and neurobehavioral performance in resident-physicians.

March 10, 2021

Cumulative effect of flexible duty-hour policies on resident outcomes: long-term follow-up results from the FIRST trial.

July 15, 2020

Effect on patient safety of a resident physician schedule without 24-hour shifts.

July 15, 2020

Association of overlapping surgery with patient outcomes in a large series of neurosurgical cases.

November 22, 2017

Race, postoperative complications, and death in apparently healthy children.

August 12, 2020

Prescribing errors in post-COVID-19 patients: prevalence, severity, and risk factors in patients visiting a post-COVID-19 outpatient clinic.

March 23, 2022

Factors influencing in-hospital prescribing errors: a systematic review.

July 19, 2023

Applying Lean Sigma solutions to mistake-proof the chemotherapy preparation process.

February 17, 2010

The effects of on-duty napping on intern sleep time and fatigue.

June 21, 2006

Advanced auditory displays and head-mounted displays: advantages and disadvantages for monitoring by the distracted anesthesiologist.

June 25, 2008

Assertive communication training for nurses to speak up in cases of medical errors: a systematic review and meta-analysis.

June 14, 2023

Barriers to incident-reporting behavior among nursing staff: a study based on the theory of planned behavior.

February 24, 2016

A multistep approach to improving biopsy site identification in dermatology: physician, staff, and patient roles based on a Delphi consensus.

March 26, 2014

Designing a safer radiology department.

March 29, 2012

Effects on resident work hours, sleep duration and work experience in a Randomized Order Safety Trial Evaluating Resident-physician Schedules (ROSTERS).

June 26, 2019

Exploring emergency physician–hospitalist handoff interactions: development of the Handoff Communication Assessment.

March 17, 2010

Physicians' views of interventions to reduce medical errors: does evidence of effectiveness matter?

April 21, 2005

A team disclosure of error educational activity: objective outcomes.

June 5, 2019

Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence.

February 27, 2019

Interdisciplinary Quality Improvement Conference: using a revised morbidity and mortality format to focus on systems-based patient safety issues in a VA hospital: design and outcomes.

November 12, 2014

Lessons learned implementing a complex and innovative patient safety learning laboratory project in a large academic medical center

January 15, 2020

An analysis of incident reports related to electronic medication management: how they change over time.

April 10, 2024

Rescue me: saving the vulnerable non-ICU patient population.

April 8, 2009

Nursing implications of an early warning system implemented to reduce adverse events: a qualitative study.

May 11, 2022

Can patient safety be measured by surveys of patient experiences?

April 30, 2008

Predictors and triggers of incivility within healthcare teams: a systematic review of the literature.

July 1, 2020

Multiple-institution comparison of resident and faculty perceptions of burnout and depression during surgical training.

May 16, 2018

Overnight stay in the emergency department and mortality in older patients.

November 29, 2023

Resident uncertainty in clinical decision making and impact on patient care: a qualitative study.

April 16, 2008

Comparison of a voluntary safety reporting system to a global trigger tool for identifying adverse events in an oncology population.

August 3, 2022

Enhancing departmental preparedness for COVID-19 using rapid-cycle in-situ simulation.

September 16, 2020

Cost of inpatient falls and cost-benefit analysis of implementation of an evidence-based fall prevention program.

February 1, 2023

Characterising the complexity of medication safety using a human factors approach: an observational study in two intensive care units.

November 6, 2013

Medication safety in two intensive care units of a community teaching hospital after electronic health record implementation: sociotechnical and human factors engineering considerations.

March 15, 2017

Association between surgical trainee daytime sleepiness and intraoperative technical skill when performing septoplasty.

October 24, 2018

How safe are paediatric emergency departments? A national prospective cohort study.

August 3, 2022

Adverse events in the paediatric emergency department: a prospective cohort study.

May 20, 2020

Self-reported adverse events in health care that cause harm: a population-based survey.

May 13, 2009

A theoretical framework and competency-based approach to improving handoffs.

May 28, 2008

Communication failures in patient sign-out and suggestions for improvement: a critical incident analysis.

December 21, 2005

Sharing lessons learned to prevent adverse events in anesthesiology nationwide.

August 21, 2019

Physician and nurse well-being and preferred interventions to address burnout in hospital practice: factors associated with turnover, outcomes, and patient safety.

July 19, 2023

The second victim of unanticipated adverse events.

December 14, 2022

Creating a framework to integrate residency program and medical center approaches to quality improvement and patient safety training

January 13, 2021

Change‐of‐shift nursing handoff interruptions: implications for evidence‐based practice.

November 6, 2019

Advancing the science of patient safety.

May 25, 2011

Moving from knowledge to action: improving safety and quality of care for patients with limited English proficiency.

February 26, 2020

Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics.

June 7, 2023

Transparency when things go wrong: physician attitudes about reporting medical errors to patients, peers, and institutions.

March 18, 2015

Effect of a multifaceted clinical pharmacist intervention on medication safety after hospitalization in persons prescribed high-risk medications: a randomized clinical trial.

March 17, 2021

'Speaking up' about patient safety concerns and unprofessional behaviour among residents: validation of two scales.

August 26, 2015

Speaking up about traditional and professionalism-related patient safety threats: a national survey of interns and residents.

May 10, 2017

Vital signs: maternity care experiences — United States, April 2023.

September 6, 2023

Where are my instruments? Hazards in delivery of surgical instruments.

August 10, 2016

Process indicators of quality clinical pharmacy services during transitions of care.

December 12, 2012

A randomized trial of nighttime physician staffing in an intensive care unit.

June 5, 2013

Two-state collaborative study of a multifaceted intervention to decrease ventilator-associated events.

June 7, 2017

A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis.

March 7, 2012

Is there a benefit to multidisciplinary rounds in an open trauma intensive care unit regarding ventilator-associated pneumonia?

February 3, 2010

Do remote community telepharmacies have higher medication error rates than traditional community pharmacies? Evidence from the North Dakota Telepharmacy Project.

September 21, 2011

Differences in medication errors between central and remote site telepharmacies.

October 17, 2012

Relation between malpractice claims and adverse events due to negligence. Results of the Harvard Medical Practice Study III.

March 27, 2005

Incidence and types of adverse events and negligent care in Utah and Colorado.

March 27, 2005

Response of practicing chiropractors during the early phase of the COVID-19 pandemic: a descriptive report.

July 8, 2020

Errors in after-hours phone consultations: a simulation study.

March 5, 2014

Evaluation of a problem-specific SBAR tool to improve after-hours nurse-physician phone communication: a randomized trial.

October 30, 2013

Liquid medication dosing errors by Hispanic parents: role of health literacy and English proficiency.

May 31, 2017

The Lancet Commission on lessons for the future from the COVID-19 pandemic.

October 12, 2022

Assessing biases in medical decisions via clinician and AI chatbot responses to patient vignettes.

November 1, 2023

Related Resources

Making Healthcare Safer IV: A Continuous Updating of Patient Safety Harms and Practices.

April 22, 2024

Patient Safety Research Summaries.

April 9, 2024

Diagnostic Quality Improvement Repository.

January 10, 2024

Validation and use of the Second Victim Experience and Support Tool questionnaire: a scoping review.

December 20, 2023

Challenge Competition: Impact of Patient Safety Tools.

December 12, 2023

Unequal Treatment Revisited: A Workshop Series.

September 26, 2023 - September 27, 2023

Global Knowledge Sharing Platform for Patient Safety.

September 20, 2023

Defining speaking up in the healthcare system: a systematic review.

September 20, 2023

Assessing the utility of ChatGPT throughout the entire clinical workflow: development and usability study.

September 13, 2023

Diagnostic errors in uncommon conditions: a systematic review of case reports of diagnostic errors.

September 13, 2023

Understanding and Improving Diagnostic Safety in Ambulatory Care.

September 6, 2023

Implementation of medication reconciliation in outpatient cancer care.

August 9, 2023

Experimental evidence for structured information-sharing networks reducing medical errors.

August 9, 2023

Patient Experience as a Source for Understanding the Origins, Impact, and Remediation of Diagnostic Errors.

August 2, 2023

Maternal Health of Women and Girls of African Descent in the Americas.

July 26, 2023

Association of polypharmacy and potential drug-drug interactions with adverse treatment outcomes in older adults with advanced cancer.

July 19, 2023

Issues and complexities in safety culture assessment in healthcare.

July 19, 2023

Identifying a list of healthcare 'never events' to effect system change: a systematic review and narrative synthesis.

July 12, 2023

Context matters: toward a multilevel perspective on context in clinical reasoning and error.

June 21, 2023

Awareness of racial and ethnic bias and potential solutions to address bias with use of health care algorithms.

June 21, 2023

Identifying electronic health record contributions to diagnostic error in ambulatory settings through legal claims analysis.

May 3, 2023

Annual Perspective

Improving Diagnostic Safety and Quality

April 26, 2023

Quality and safety: learning from the past and (re)imagining the future.

March 29, 2023

Using Failure Mode, Effect and Criticality Analysis to improve safety in the cancer treatment prescription and administration process.

March 8, 2023

Towards conceptualizing patients as partners in health systems: a systematic review and descriptive synthesis.

March 8, 2023

The impact of medication reconciliation and review in patients using oral chemotherapy.

March 1, 2023

The role of bias in clinical decision-making of people with serious mental illness and medical co-morbidities: a scoping review.

February 22, 2023

AHRQ-Funded Patient Safety Project Highlights: Improving Healthcare Safety by Engaging Patients and Families.

February 15, 2023

The value of learning from near misses to improve patient safety: a scoping review.

January 25, 2023

The REPAIR Project: a prospectus for change toward racial justice in medical education and health sciences research: REPAIR project steering committee.

January 11, 2023

See More About The Topic

Hospitals

Ambulatory Clinic or Office

Medicine

Medical Oncology

Medication Errors/Preventable Adverse Drug Events

Preventing potential patient harm through clinical content interventions during oncology clinical trial implementation.

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

Preventing potential patient harm through clinical content interventions during oncology clinical trial implementation.

Connect With Us

Sign up for Email Updates

Agency for Healthcare Research and Quality

Submit Your Innovations

Continue as a Guest

Continue Logged In

Submit Your Innovations

Continue as a Guest

Continue logged in

New Users to the PSNet site