This commentary discusses the current systemwide limitations in measuring physician performance and how this deficiency compromises the ability to provide high-quality and safe patient care. The authors provide a background and contextual basis for definitions such as professional competence and disruptive behavior before examining the extent of the problem. They build on past efforts of measures to predict unprofessional or disruptive behavior and discuss a model and strategy for addressing physician performance nationally. The authors conclude with a call to action for organizations best positioned to lead this charge, including the American Board of Medical Specialties and the Joint Commission on Accreditation of Healthcare Organizations.