Interventions to improve patient safety also contribute to physician burnout (e.g., decision support systems to reduce medication errors can result in alert fatigue and excessive time spent in the electronic health record). This commentary recommends several actions to reduce physician burnout while still maintaining patient safety: consider the impact of interventions on physician well-being, reduce the burden of documentation, offload some documentation to non-physicians/non-clinicians, coordinate training courses, rethink maintenance of certification, and take a multi-pronged approach that focuses on individual, departmental, institutional, and national concerns.