Journal Article

Reasons provided by prescribers when overriding drug–drug interaction alerts.

Grizzle AJ; Mahmood MH; Ko Y; Murphy JE; Armstrong EP; Skrepnek GH; Jones WN; Schepers GP; Nichol WP; Houranieh A; Dare DC; Hoey CT; Malone DC.

This study discovered that more than 70% of overrides identified in a computerized provider order entry (CPOE) system were for critical drug–drug interactions. The authors also point out that 53% of providers offered no clinical justification for such overrides, raising questions about the system’s need for redesign.