Reasons provided by prescribers when overriding drug–drug interaction alerts.
Grizzle AJ, Mahmood MH, Ko Y, et al. Reasons provided by prescribers when overriding drug-drug interaction alerts. Am J Manag Care. 2007;13(10):573-578.
This study discovered that more than 70% of overrides identified in a computerized provider order entry (CPOE) system were for critical drug–drug interactions. The authors also point out that 53% of providers offered no clinical justification for such overrides, raising questions about the system’s need for redesign.