This application-oriented book provides the results of the Institute for Healthcare Improvement (IHI) Breakthrough Series program focusing on decreasing adverse drug events in health care facilities. More than 40 organizations share their collective learning experience, from planning for improvement, testing ideas, studying what they learned, and implementing change. The book’s numerous case studies, descriptions of step-wise improvement processes, and strategies for breaking down organizational barriers help illustrate the experience and methods that led to the group’s success. The book will be valuable to individuals and institutions attacking the problem of medication errors or seeking insight into collaborative learning models.