Based on survey data, this study explored intrapersonal, interpersonal and organizational triggers resulting in disruptive and unprofessional behavior. All three types of triggers were significantly related to disruptive behavior among nurses; intrapersonal and interpersonal triggers were significantly related to disruptive behavior among clinicians. The most frequent triggers included pressures from high census; environmental overload; chronic, unresolved system issues; and personal characteristics or issues impeding job performance.