This conference focused on persisting barriers to patient safety worldwide and recommended strategies to achieve lasting improvement, including dedication to systems engineering, patient-centeredness, and process integration. The session summarized findings of a report developed for the event, Transforming Patient Safety: a Sector-wide Systems Approach. The proceedings collection includes the full text of the report, video of the panel, and podcasts with Margaret Murphy, Dr. Mary Dixon-Woods, Dr. Peter Pronovost, and other participants.