This editorial discusses how adverse events can occur if standardized order sets in computerized provider order entry systems are based on outdated or equivocal evidence. The authors outline a process for ensuring order sets and decision support systems contain current and valid evidence in order to maximize their effectiveness and minimize risk to patients. The editorial is based on a case described in the related article.

Diagnostic error has gained recognition as a contributor to patient harm. This commentary explores physician diagnostic calibration—the relationship between individual confidence in diagnostic decision making and diagnostic accuracy—including factors that influence it.