The AHRQ PSNet Collection comprises an extensive selection of resources relevant to the patient safety community. These resources come in a variety of formats, including literature, research, tools, and Web sites. Resources are identified using the National Library of Medicine’s Medline database, various news and content aggregators, and the expertise of the AHRQ PSNet editorial and technical teams.
Murphy DR, Zimolzak AJ, Upadhyay DK, et al. J Am Med Inform Assoc. 2023;30:1526-1531.
Measuring diagnostic performance is essential to identifying opportunities for improvement. In this study, researchers developed and evaluated two electronic clinical quality measures (eCQMs) to assess the quality of colorectal and lung cancer diagnosis. Each measure used data from the electronic health record (EHR) to identify abnormal test results, evidence of appropriate follow-up, and exclusions that signified unnecessary follow-up. The authors describe the measure testing results and outline the challenges in working with unstructured EHR data.
Feather C, Appelbaum N, Darzi A, et al. BMJ Qual Saf. 2023;32:357–368.
Requiring a prescriber to include an indication for a medication can reduce the risk of wrong-patient orders and improve antimicrobial and opioid stewardship. This review identified 21 studies describing interventions to encourage prescribers to include indications for medications. In addition to patient safety benefits, several risks and drawbacks were uncovered, such as potential loss of patient privacy or alert fatigue.
Kelly D, Koay A, Mineva G, et al. Public Health. 2022;214:50-60.
Natural disasters and other public health emergencies (PHE), such as the COVID-19 pandemic, can dramatically change the delivery of healthcare. This scoping review identified considerable research examining the relationship between public health emergencies and disruptions to personal medication practices (e.g., self-altering medication regimens, access barriers, changing prescribing providers) and subsequent medication-related harm.
Sutherland A, Jones MD, Howlett M, et al. Drug Saf. 2022;45:881-889.
Intravenous (IV) medication smart pumps can improve medication administration, but usability issues can compromise safety. This article outlines strategic recommendations regarding the implementation of smart pump technology to improve patient safety. Recommendations include standardization of infusion concentrations, improving drug libraries using a human-centered approach, and increasing stakeholder engagement.
Jones MD, Clarke J, Feather C, et al. Ann Pharmacother. 2021;55:1333-1340.
Medication errors during pediatric resuscitation are common. Using video recordings of simulated pediatric resuscitations, the researchers explored deviations in care related to the delivery of intravenous medicine. Findings suggest that deviations play a crucial role in intravenous medication administration errors, and deviations were more likely to occur during the use of an online injectable medicine guideline.
Chaudhry NT, Franklin BD, Mohammed S, et al. Pharmacy (Basel). 2021;9:198.
Data that is collected for clinical care and then reused to improve quality of patient care is referred to as secondary use of data (SUD). This review identified enablers and barriers to successful use of SUD to improve medication safety. The authors developed an integrated framework to describe the processes, mechanisms, and barriers for SUD.
In 2017, the World Health Organization (WHO) introduced the third Global Patient Safety Challenge, Medication Without Harm. Interviews, focus groups, and document analysis were conducted at four UK hospitals to evaluate how they were addressing the domains and priority areas laid out in the WHO’s Patient Safety Challenge. Although all areas were addressed, additional focus is needed on patient and public involvement, transitions of care, and polypharmacy.
Vaghani V, Wei L, Mushtaq U, et al. J Am Med Inform Assoc. 2021;28:2202-2211.
Based on the Safer Dx and SPADE frameworks, researchers applied a symptom-disease pair-based electronic trigger (e-trigger) to identify patients hospitalized for stroke who had been previously discharged from the emergency department with a diagnosis of headache or dizziness in the preceding 30 days. Analyses show that the e-trigger identified missed diagnoses of stroke with a modest positive predictive value.
Jones MD, McGrogan A, Raynor DK, et al. BMJ Qual Saf. 2021;2021:17-26.
This study compared the frequency of intravenous (IV) medication errors using the current National Health Service Injectable Medicines Guide (IMG) versus revised IMG-based user-testing, which included such revisions as provision of equations and tables to support rate calculations. Findings indicate that user-tested guidelines led to fewer medication errors, less time to prepare and administer IV medications, and increased staff confidence.
Härkänen M, Paananen J, Murrells T, et al. BMC Health Serv Res. 2019;19:791.
This retrospective study used text mining to analyze the free text descriptions in 72,390 medication administration incident reports in the National Reporting and Learning System in England and Wales to identify terms most frequently associated with risk that might otherwise remain buried within other non-relevant text. The authors identified the most common medications described in free text (insulin, antibiotics, paracetamol and morphine) and presented the most common free text terms associated with these medications. Results indicate that checking patient allergies and medication doses, especially for intravenous and transdermal medications, should be a focus of efforts to increase medication administration safety.
Garfield S, Furniss D, Husson F, et al. BMJ Qual Saf. 2020;29:764-773.
This mixed-methods study of patients, caregivers and healthcare professionals explores how patient-held medication lists (such as paper medication lists, medication diaries, or apps) can support patient safety. Patient-held lists can improve medication safety by improving the accuracy of medication reconciliation, identifying potential drug interactions, and facilitating communication.
Appelbaum N, Clarke J, Feather C, et al. BMJ Open. 2019;9:e032686.
While medication errors during paediatric resuscitation are considered common, little information about the processes that contribute to them has been gathered. This prospective observational study in a large English teaching hospital describes the incidence, nature and severity of medication errors made by 15 teams, each comprised of two doctors and two nurses, during simulated paediatric resuscitations. Clinically significant errors were made in 11 of the 15 cases, most due to discrepancies in drug ordering, preparation and administration. The authors recommend additional research into new approaches to protecting patients in paediatric emergency settings.
Blandford A, Dykes PC, Franklin BD, et al. Drug Saf. 2019;42:1157-1165.
Intravenous medication infusions are an important target for safety interventions. Many infused medications, such as opioids and chemotherapy, require vigilant adherence to protocol to prevent harm. Technical solutions to infusion errors such as computerized provider order entry, barcode medication administration, and smart infusion pumps have been implemented with some success. Investigators compared infusion errors in the United States, where all three technical interventions are common, to the United Kingdom, where those technical interventions are rare. Minor errors were common in each country, but only 0.8% of infusions placed patients at serious risk of harm. Although the details of errors in both countries differed in detail, rates of error and harm were similar. A WebM&M commentary described a chemotherapy infusion error that caused renal failure.
Puaar SJ, Franklin BD. BMJ Qual Saf. 2018;27:529-538.
Computerized provider order entry (CPOE) has vastly improved medication safety when compared to handwritten orders. However, even with CPOE, medication ordering errors are common. This qualitative study used a human factors approach to characterize electronic prescribing errors, which were primarily due to CPOE system design, organizational implementation decisions, and individual prescribing behaviors. A PSNet perspective assessed lessons learned about electronic health record safety.
Lyons I, Furniss D, Blandford A, et al. BMJ Qual Saf. 2018;27:892-901.
Errors and discrepancies in intravenous infusions were common in this study performed at two English hospitals, but only a small proportion of errors led to patient harm. The use of smart pumps did not appear to protect against errors.
Murphy DR, Meyer AND, Vaghani V, et al. J Am Coll Radiol. 2018;15:287-295.
Electronic triggers are critical tools for detecting adverse events, diagnostic errors, and other safety hazards. Researchers developed an electronic health record–based trigger tool to identify delays in abnormal mammogram follow-up at Veterans Affairs facilities. The tool was moderately effective in detecting diagnostic and treatment delays (positive predictive value 71%) and rarely failed to identify a delay (negative predictive value 93%). Inability to schedule timely follow-up and other systems issues were the most common sources of delay. This study is a rigorous example of how trigger tools can detect safety hazards and improve timely cancer diagnosis. A recent Annual Perspective describes how electronic health records can both help and hinder patient safety.