Children with medical complexity (CMC) frequently take multiple medications, often from multiple prescribers. This commentary describes the particular vulnerabilities CMC face throughout the medication use cycle, along with ways for the prescriber and system to mitigate the risks of polypharmacy.

Parents or caregivers of children with serious medical conditions who reside at home must balance caregiving demands with other competing responsibilities, such as raising other children, working or maintaining a home – often resulting in unsafe workload. This commentary discusses the need for safe work-hour standards for home caregivers to ensure the well-being and safety of both children and caregivers.

… prescribing , look-alike and sound-alike drug names remain a safety vulnerability. In 2007, the Food and Drug … are printed in capital letters to avoid being mistaken for a look-alike or sound-alike medication (e.g., DOPamine; …

This study assessed an error of omission—failure to assess children for occult fractures—in several clinically indicated situations, and found that such errors occur in about half of cases. Interventions to prompt specific actions, like checklists, may be useful in this clinical arena.

This retrospective cohort study found that children with complex chronic conditions are at higher risk for adverse drug events that lead to emergency department visits but not hospital admissions, compared with other children. Psychotropic medications were the most common cause of adverse drug events in this vulnerable population.

… multiple, often similar medications) has been shown to be a risk factor for adverse drug events. This study used data from a national database to document a striking incidence of polypharmacy among hospitalized …