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Carfora L, Foley CM, Hagi-Diakou P, et al. PLoS ONE. 2022;17:e0267030.
Patients are frequently asked to complete patient-reported outcome measures (PROM), or standardized questionnaires, to assess general quality of life, screen for specific conditions or risk factors, and perspectives on their health. This review identified 14 studies related to patient perspectives regarding PROMs. Three themes emerged: patient preferences regarding PROMs, patient perceived benefits, and barriers to patient engagement with PROMs.
Riblet NB, Gottlieb DJ, Watts BV, et al. J Nerv Ment Dis. 2022;210:227-230.
Unplanned discharges (also referred to as leaving against medical advice) can lead to adverse patient outcomes. This study compared unplanned discharges across Veterans Health Affairs (VHA) acute inpatient and residential mental health treatment settings over a ten-year period and found that unplanned discharges are significantly higher in mental health settings. The authors recommend that unplanned discharges be measured to assess patient safety in mental health.
Essex R, Weldon SM. Nurs Ethics. 2022;Epub Apr 12.
Appropriate staffing levels have been shown to impact patient safety and patient outcomes. This review of literature on healthcare worker strikes explores potential negative impacts, such as compromised patient safety due to decreased staffing levels, and justifications, such as long-term benefits.
Navathe AS, Liao JM, Yan XS, et al. Health Aff (Millwood). 2022;41:424-433.
Opioid overdose and misuse continues to be a major public health concern with numerous policy- and organization-level approaches to encourage appropriate clinician prescribing. A northern California health system studied the effects of three interventions (individual audit feedback, peer comparison, both combined) as compared to usual care at several emergency department and urgent care sites. Peer comparison and the combined interventions resulted in a significant decrease in pills per prescription.
Alboksmaty A, Beaney T, Elkin S, et al. The Lancet Digital Health. 2022;4:e279-e289.
The COVID-19 pandemic led to a rapid transition of healthcare from in-person to remote and virtual care. This review assessed the safety and effectiveness of pulse oximetry in remote patient monitoring (RPM) of patients at home with COVID-19. Results show RPM was safe for patients in identifying risk of deterioration. However, it was not evident whether remote pulse oximetry was more effective than other virtual methods, such as virtual visits, monitoring consultations, or online or paper diaries.
Casalino LP, Li J, Peterson LE, et al. Health Aff (Millwood). 2022;41:549-556.
Physician burnout has been associated with higher rates of self-reported medical errors and increased costs related to physician turnover. This analysis linked survey data from family physicians to Medicare claims to explore any association of burnout with four objective measures of care outcomes (ambulatory care-sensitive admissions, ambulatory care-sensitive emergency department visits, readmissions, or costs). There was no consistent, statistically significant relationship between burnout and the four measures of care outcomes and further research on this relationship is warranted.
Nowak B, Schwendimann R, Lyrer P, et al. Int J Environ Res Public Health. 2022;19:2796.
Diagnostic error and misdiagnosis of stroke patients can lead to preventable adverse events, such as treatment delays and adverse outcomes. Researchers at a Swiss hospital retrospective reviewed patients admitted for transient ischemic attack (TIA) or ischemic stroke and found that a trigger tool could accurately identify preventable events among patients with adverse events and no-harm incidents. The most common preventable events were medication events, pressure injuries, and healthcare-associated infections.

Rockville, MD: Agency for Healthcare Research and Quality; April 7, 2022. RFA-HS-22-008.

Improving diagnosis and reducing diagnostic errors are patient safety priorities. This announcement supports the development of Diagnostic Centers of Excellence focused on improving frontline diagnostician support and improving diagnostic systems (i.e., improving diagnostic precision through consensus, improving “truth” or diagnostic reference standards). Applications are due by June 9, 2022.
Willis E, Brady C. Nurs Open. 2022;9:862-871.
Incomplete nursing care can negatively affect care quality and safety. This rapid review found that missed or omitted nursing care in adults contributes to increased mortality, adverse events, and clinical deterioration. Included studies cited several causes (e.g., environmental factors, staffing levels and skill mix) as well as solutions (e.g., education, process redesign).
Brierley-Jones L, Ramsey L, Canvin K, et al. Res Involv Engagem. 2022;8:8.
Patient engagement in safety efforts is encouraged, but patients are less often included as active participants in designing patient safety interventions. This review identified 52 studies that included mental health patients in the design, delivery, implementation, and/or evaluation of patient safety research. The authors argue that increased inclusion of patients in safety research may lead to development of higher quality safety interventions.

Garb HN. Psyche. March 22, 2022.

A wide array of biases can affect clinical judgement and contribute to diagnostic error. This article discusses the impact of implicit biases, test inaccuracy, and data weaknesses in diagnosis of mental health conditions in both children and adults. The author provides recommendations for clinicians and researchers to reduce the impact of bias on diagnosis.
Damoiseaux-Volman BA, Raven K, Sent D, et al. Age Ageing. 2022;51:afab205.
According to an Agency for Healthcare Research and Quality study, an estimated 700,000 to 1 million hospitalized patients fall each year. This study assessed the impact of potentially inappropriate medications (PIM) on falls in older adults and compared the impact of three deprescribing tools on inpatient falls. PIMs identified by section K of the Screening Tool of Older Persons' Prescriptions (STOPP) had the strongest association with inpatient falls.
Irons MW, Auta A, Portlock JC, et al. Home Health Care Serv Q. 2022;41:91-123.
Care home residents experience high rates of medication errors. Thirty-two articles about medication errors in UK care homes were included in this review. Articles covered causes, rates, recommendations, and/or evaluation of interventions on error rates. The authors recommend development of more robust strategies for evaluating medication errors in care homes.
Marshall TL, Rinke ML, Olson APJ, et al. Pediatrics. 2022;149:e2020045948D.
Reducing diagnostic errors in pediatric care remains a critical area of research and quality improvement. This narrative review presents the incidence and epidemiology of pediatric diagnostic error and strategies for additional innovative research to develop effective interventions to reduce these errors.
Al-Ghunaim TA, Johnson J, Biyani CS, et al. Am J Surg. 2022;224:228-238.
Burnout in healthcare providers has been linked to lower patient safety and increased adverse events. This systematic review examined studies focusing on the relationship between burnout and patient safety and professionalism in surgeons. Results indicate higher rates of burnout and emotional exhaustion were associated with an increased risk of involvement in medical error. Interventions to reduce burnout and improve surgeon well-being may result in improved patient safety.
Dorken Gallastegi A, Mikdad S, Kapoen C, et al. J Surg Res. 2022;274:185-195.
While interoperative deaths (IODs) are rare, they are catastrophic events. This study analyzed five years of data on IODs from a large academic medical center. The authors describe three phenotypes: patients with traumatic injury, those undergoing non-trauma-related emergency surgery, and patients who die during an elective procedure from medical cardiac arrests or vascular injuries. This classification framework can serve as a foundation for future research or quality improvement processes.

Palo Alto CA; Gordon and Betty Moore Foundation: February 22, 2022. 

A lack of consensus on measures for the effectiveness and accuracy of diagnosis represents a gap in improvement methods. This announcement seeks proposals to examine quality measures to motivate excellence in three primary areas of diagnostic concern:  acute vascular events, infections, and cancer. The deadline to submit for the next round of funding is May 16, 2022.
Sun LY, Jones PM, Wijeysundera DN, et al. JAMA Netw Open. 2022;5:e2148161.
Previous research identified a relationship between anesthesia handoffs and rates of major complications and mortality compared to patients who had the same anesthesiologist throughout their procedure. This retrospective cohort study including over 102,000 patients in Ontario, Canada, explored this relationship among patients undergoing cardiac surgery. Analyses revealed that anesthesia handovers were associated with poorer outcomes (i.e., higher 30-day and one-year mortality rates, longer hospitalizations and intensive care unit stays) compared with patients who had the same anesthesiologist throughout their procedure.
Klein DO, Rennenberg RJMW, Koopmans RP, et al. J Patient Saf. 2021;17:e1234-e1240.
The Harvard Medical Practice Study (HMPS) and the Institute for Healthcare Improvement Global Trigger Tool (GTT) are two of the most widely used trigger tools to identify adverse events and prompt medical record review. Fifty studies using either trigger tool to prompt a medical record review (MRR) for potentially preventable adverse events were included in this literature review. MRR reveals more adverse events than other methods; however, research is still lacking or is of moderate quality. 

Bethesda, MD: National Institute of Neurological Disorders and Stroke. February 10, 2022. Publication No. NOT-NS-22-071.

Approaching diagnosis as a team activity is seen as a key approach to diagnostic effectiveness. This notice highlights the pending funding opportunity to launch Diagnostic Centers of Excellence to improve diagnosis of undiagnosed and unknown disease and research to inform improvement. In addition, a pending data coordination and management call for proposals to support the centers has been released.