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Bulliard J‐L, Beau A‐B, Njor S, et al. Int J Cancer. 2021;149:846-853.
Overdiagnosis of breast cancer and the resulting overtreatment can cause physical, emotional, and financial harm to patients. Analysis of observational data and modelling indicates overdiagnosis accounts for less than 10% of invasive breast cancer in patients aged 50-69. Understanding rates of overdiagnosis can assist in ascertaining the net benefit of breast cancer screening.
Liew TM, Lee CS, Goh SKL, et al. Age Ageing. 2020.
Potentially inappropriate prescribing in older adults can lead to adverse health outcomes and worsened health-related quality of life. This meta-analysis estimated the prevalence of potentially inappropriate prescribing in older adults to be 3.3%, and estimated that potentially inappropriate prescribing explains 7.7 to 17.3% of adverse outcomes affecting older adults in primary care. Interventions to prevent potentially inappropriate prescribing should be prioritized as a key strategy to reduce medication-related harm along older adults in primary care settings.
Huang C-H, Umegaki H, Watanabe Y, et al. PLOS ONE. 2019;14:e0211947.
Various tools for identifying potentially inappropriate medications (PIMs) have been developed. This 5-year prospective cohort study of 196 elderly patients receiving home-based medical services in Japan compared the use of two tools for identifying PIMs, the American Geriatrics Society’s Beers Criteria and the relatively new Screening Tool for Older Person’s Appropriate Prescriptions for Japanese (STOPP-J), to determine the impact of PIMs on hospitalization and mortality rates. PIMs categorized by STOPP-J were associated with hospitalization and mortality, whereas Beers Criteria PIMs were associated with hospitalization only after excluding proton pump inhibitors.