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Whitaker B. CBS News. May 22, 2022.

Drug shortages represent a complex system level challenge in health care that can harm patients. This news segment details economic and production factors that affect the availability of generic medications. Clinicians and families were interviewed to share tactics for managing these situations to support patient safety despite shortages.
Lin MP, Vargas-Torres C, Shin-Kim J, et al. Am J Emerg Med. 2022;53:135-139.
Drug shortages can result in patient harm, such as dosing errors from a medication substitution. In this study, 28 of the 30 most frequently used medications in the emergency department experienced shortages between 2006 and 2019. The most common reasons for shortages were manufacturing delays and increased demand. The COVID-19 pandemic exacerbated pre-existing drug shortages.

Bookwalter CM. US Pharmacist. 2021;46(2):25-28. 

 

COVID-19 has increased uncertainties in sectors across health care. This article discusses a variety of supply-chain factors that impact medication availability. The author suggests roles for pharmacists in antibiotic stewardship and policy implementation to manage shortages safely.
Miller FA, Young SB, Dobrow M, et al. BMJ Qual Saf. 2020;30:331-335.
The COVID-19 pandemic has raised concerns about medical product shortages and demand surges, and the resulting effects on patient safety. This viewpoint discusses medical product supply chain vulnerabilities heightened by the COVID-19 pandemic. The authors summarize the evidence on supply chain resilience and medical product shortage, provide examples to illustrate key vulnerabilities, and discuss reactive and proactive solutions for medical product shortage.
Piatek OI, Ning JC-min, Touchette DR. Am J Health Syst Pharm. 2020;7:1778-1785.
Drug shortages are an ongoing threat to safe patient care. This commentary discusses the impact of COVID-19 on medication supply and demand, and the resulting drug shortages. The authors provide several recommendations for reducing future drug shortages in times of crises, including increasing stockpiles and creating a critical drug list with potential substitutes.
Girion L, Levine D, Respaut R. Reuters. 2020;June 9.
The COVID-19 pandemic has disrupted the supply of protective equipment, medical devices and medications. This article discusses how economics contribute to drug shortages and highlights the specific impact on access to the opioids essential for providing safe care for hospitalized patients with COVID-19.
Alexander GC, Qato DM. JAMA. 2020;324:31-32.
The COVID-19 pandemic has raised concerns about the pharmaceutical supply chain, from overseas manufacturing to medication distribution within the United States. This commentary presents several emergency response and preparedness measures for policymakers, pharmaceutical distributors and pharmacies to prepare for drug shortages and demand surges. Suggested measures include developing an “essential medicines” strategy, using allocation strategies that prevent stockpiling and drug shortages and expanding capacity for mail-order and home delivery.
Rabin RC. Faced with a drug shortfall, doctors scramble to treat children with cancer. New York Times. October 14, 2019.
Drug shortages create potential complexities in drug therapy that can result in unsafe medication use. This story examines a vincristine shortage affecting pediatric patients.  Systemic factors contributing to the problem discussed include medications produced by a single supplier and workarounds when supplies are threatened. 
Alpert A, Jacobson M. Clin Pharmacol Ther. 2019;106:415-421.
Drug shortages have become more frequent and may lead to delays in treatment or failure to deliver the appropriate drug, an error of omission. This secondary data analysis examined how oncology drug shortages affected use of chemotherapy medications among patients with newly diagnosed cancer as measured by Medicare claims data. The changes in utilization varied by medication; overall, drug shortages had only a modest impact on the delivery of these drugs to patients with newly diagnosed cancer. This finding contrasts with a prior study showing patient harm related to drug shortages, and the authors recommend further study to understand how to identify and mitigate clinically relevant drug shortages. A WebM&M commentary discussed strategies for preventing or minimizing adverse events associated with drug shortages.
Banerjee R, Thurm CW, Fox ER, et al. Pediatrics. 2018;142.
Drug shortages can disrupt care processes and diminish medication safety. This commentary highlights distinct concerns associated with disruptions in access to appropriate antibiotics for pediatric patients and the lack of evidence exploring this common problem. The authors suggest strategies to address these shortages, including antibiotic stewardship and government oversight. A WebM&M commentary discussed challenges associated with medication shortages.
Fox ER, McLaughlin MM. Am J Health Syst Pharm. 2018;75:1742-1750.
Drug shortages are a persistent threat to safe patient care. These guidelines provide a structured approach for care teams to develop an action plan to reduce risks when faced with drug shortages in their work. Recommendations include conducting operational assessments, establishing a drug shortage team, and communicating with patients and providers when a shortage occurs.
Am J Health Syst Pharm. 2018;75:816-820.
This commentary summarizes the discussion of a multidisciplinary group of experts about drug shortages to highlight successes, opportunities for improvement, trends to consider, and strategies to plan for shortages. The group recommended actions needed to guide prevention and mitigation efforts such as developing best practices for use of high-alert drugs during shortages, increasing manufacturer transparency, and enhancing Food and Drug Administration improvement and communication activities.
National Alert Network. Horsham, PA: Institute for Safe Medication Practices; Bethesda, MD: American Society of Health-System Pharmacists. May 24, 2018.
Drug shortages can necessitate hospitals to find alternative sources for important medications. This alert raises awareness of risks associated with potassium chloride use due to variations in labeling, packaging, or concentration of outsourced medications. Recommendations include use of barcode scanning and communicating with staff regarding drug shortages.
University of Utah Drug Information Service; ASHP; American Society of Health-System Pharmacists.
Efforts to limit the availability of opioids has led to a shortage of needed medications. This fact sheet provides strategies for organizations who seek to improve management of injectable opioids while taking into account both safety and supply availability.
Holcombe B, Mattox TW, Plogsted S. Nutr Clin Pract. 2018;33:53-61.
Shortages of medications and compounding components can lead to diversion from recommended treatment. This review describes problems that can arise due to shortages in parenteral nutrition components. The authors recommend strategies to reduce risks associated with lack of ingredients for parenteral nutrition.

ISMP Medication Safety Alert! Acute Care Edition. January 11, 2018;23:1-4.

Drug shortages are known to disrupt the safety of care. This newsletter article reports the results of a survey exploring the impact of drug shortages on practice and recommends strategies to help organizations safely manage drug shortages, including standardizing processes and raising awareness among clinicians regarding shortages.