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Diagnostic error and misdiagnosis of stroke patients can lead to preventable adverse events, such as treatment delays and adverse outcomes. Researchers at a Swiss hospital retrospective reviewed patients admitted for transient ischemic attack (TIA) or ischemic stroke and found that a trigger tool could accurately identify preventable events among patients with adverse events and no-harm incidents. The most common preventable events were medication events, pressure injuries, and healthcare-associated infections.

Prior research has found that racial/ethnic minorities may be at higher risk for adverse patient safety outcomes. This study evaluated racial disparities in self-reported adverse events based on cross-sectional survey data collected as part of a national, prospective cohort evaluating stroke mortality. Findings show that Black participants were significantly more likely to report a preventable adverse event attributable to poor care coordination (e.g., drug-drug interaction, emergency department visitor, or hospitalization) compared to White participants.

Based on the Safer Dx and SPADE frameworks, researchers applied a symptom-disease pair-based electronic trigger (e-trigger) to identify patients hospitalized for stroke who had been previously discharged from the emergency department with a diagnosis of headache or dizziness in the preceding 30 days. Analyses show that the e-trigger identified missed diagnoses of stroke with a modest positive predictive value.

A missed or delayed diagnosis of stroke increases the risk of permanent disability or death. This retrospective study compared rates of misdiagnosed stroke in patients presenting to general care or specialty care who were initially diagnosed with “benign dizziness”. Patients with dizziness who presented to general care were more likely to be misdiagnosed than those presenting to specialty care. Interventions to improve stroke diagnosis in emergency departments may also be successful in general care clinics.

Alteplase and other thrombolytics are high-alert medications. This study compared error rates of alteplase administration in patients presenting with acute ischemic stroke at either a regional hospital or a Comprehensive Stroke Center (CSC) and found that community hospitals had over a 10 times greater number of errors leading to hemorrhage. The study recommend to put safeguards in place to decrease the risk of alteplase medication administration errors.

The ”weekend effect” refers to worse patient outcomes occurring outside of usual business hours. The authors used national data to examine in-hospital mortality differences among patients experiencing stroke admitted on the weekend versus on a weekday. After adjusting for patient and hospital characteristics, in-hospital mortality among hemorrhagic stroke patients was significantly greater among weekend compared to weekday admissions. No weekend effect was found among ischemic stroke patients. Future research should explore the influence of additional factors, such as patient-level behavioral risk factors and the availability of care providers and stroke care centers, particularly in rural regions.  

Delayed diagnosis and treatment are common patient safety issues with significant adverse outcomes for patients. Analyzing nearly 300 medical malpractice cases related to acute care of stroke patients, this review found that the majority of malpractice lawsuits alleged failure of timely diagnosis and treatment. The majority of cases resulted in no payout, but those that did result in payout saw an average settlement in excess of $1.8 million in settlements and $9.7 million in plaintiff verdicts. 

This commentary describes an incident involving diagnostic error and substandard care of a patient with disability. The author cautions against assumptions about individuals with disabilities that can compromise care. A PSNet commentary discussed the impact of diagnostic overshadowing on patient care.

This retrospective study of patients with a diagnosis of multiple sclerosis found that nearly 20% had been misdiagnosed and did not have the disease. The authors highlight the risks from misdiagnosis including exposure to high-risk medications with resultant adverse drug events and delay in correct treatment for patient conditions.

Rare diseases pose diagnostic challenges for physicians. This commentary offers insights from parents of a young child who died due to a delayed stroke diagnosis as well as from the patient's neurologist to raise awareness of childhood stroke and discuss the importance of partnership to heal from loss and advocate for improvement.

This analysis of Medicare claims data found a significant prevalence of concurrent use of dementia medication with acetylcholinesterase inhibitors and anticholinergic medications. This medication combination is a frank medical error that the authors describe as a never event. Despite this, coprescription occurred in 44% of those prescribed dementia medication, and this medication error was more common in the southeastern and midwestern regions of the United States compared to the northeast or western regions.

Prior research has shown that polypharmacy in elderly patients with dementia is associated with a greater risk of functional decline. This cross-sectional study of Danish patients age 65 and older found that polypharmacy and potentially inappropriate medication use were common in this population and were more frequent among patients with dementia.