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Vallamkonda S, Ortega CA, Lo YC, et al. Stud Health Technol Inform. 2022;290:120-124.
Prior research has found that electronic health record (EHR) implementation has introduced risks to patient safety. Using data from one hospital’s EHR system, this study reviewed active allergy alerts in patient records and concluded that 37% of those records required reconciliation of allergy information across different areas of the EHR. These findings highlight the need for automated reconciliation algorithms and clinical decision support tools to help clinicians identify potential allergy discrepancies and avoid patient safety risks.
Phadke NA, Wickner PG, Wang L, et al. J Allergy Clin Immunol Pract. 2022;Epub Apr 7.
Patient exposure to allergens healthcare settings, such as latex or certain medications, can lead to adverse outcomes. Based on data from an incident reporting system, researchers in this study developed a system for classifying allergy-related safety events. Classification categories include: (1) incomplete or inaccurate EHR documentation, (2) human factors, such as overridden allergy alerts, (3) alert limitation or malfunction, (4) data exchange and interoperability failures, and (5) issues with EHR system default options. This classification system can be used to support improvements at the individual, team, and systems levels. 

Errors in medication management and administration are major threats to patient safety. This piece explores issues with opioid and nursing-sensitive medication safety as well as medication safety in older adults. Future research directions in medication safety are also discussed.

Ang D, Nieto K, Sutherland M, et al. Am Surg. 2022;88:587-596.
Patient safety indicators (PSI) are measures that focus on quality of care and potentially preventable adverse events. This study estimated odds of preventable mortality of older adults with traumatic injuries and identified the PSIs that are associated with the highest level of preventable mortality.  Strategies to reduce preventable mortality in older adults are presented (e.g. utilization of national guidelines, minimization of central venous catheter use, addressing polypharmacy).
Alshehri GH, Ashcroft DM, Nguyen J, et al. Drug Saf. 2021;44:877-888.
Adverse drug events (ADE) can occur in any healthcare setting. Using retrospective record review from three mental health hospitals, clinical pharmacists confirmed that ADEs were common, and that nearly one-fifth of those were considered preventable.

Lazris A, Roth AR, Haskell H, et al. Am Fam Physician. 2021;103(12):757-759.  

Communication failures are primary threat to safe care. This commentary shares insights on communication problems that contributed to unsafe medication prescribing from both a clinicians and a patient/family perspective.
Kakemam E, Chegini Z, Rouhi A, et al. J Nurs Manag. 2021;29:1974-1982.
Clinician burnout, characterized by emotional exhaustion, depersonalization, and decreased sense of accomplishment, can result in worse patient safety outcomes. This study explores the association of nurse burnout and self-reported occurrence of adverse events during COVID-19. Results indicate higher levels of nurse burnout were correlated with increased perception of adverse events, such as patient and family verbal abuse, medication errors, and patient and family complaints. Recommendations for decreasing burnout include access to psychosocial support and human factors approaches.

José A, Morfín, MD, FASN, is a health sciences clinical professor at the University of California Davis School of Medicine. In his professional role, he serves as the Medical Director for Satellite Health Care and as a member of the Medical Advisory Board for Nx Stage Medical. We discussed with him home dialysis and patient safety considerations.

American Society of Pharmacovigilance.

Adverse drug events (ADEs) are common and contribute to patient harm. This campaign provides materials to raise general awareness of the impact of ADEs on care, hospital admissions, and costs.
Dürr P, Schlichtig K, Kelz C, et al. J Clin Oncol. 2021;39:1983-1994.
Patients taking oral anti-cancer drugs may experience severe side effects and medication errors. In this randomized controlled study, patients taking oral chemotherapy drugs were randomized to receive usual care (control) or additional intensive pharmacological/pharmaceutical care (intervention). Patients in the intervention group reported considerably fewer medication errors and side effects and increased treatment satisfaction.
Sarasin DS, Brady JW, Stevens RL. Anesth Prog. 2020;67(1):48-59. 
This two-part series discusses anesthesia- and sedation-related medication errors and adverse events in healthcare and dentistry (part 1) and how these errors impact dentistry and approaches to address these issues within a dental anesthesia medication safety paradigm - the Dental Anesthesia Medication Safety Paradigm (DAMSP) - which offers four general guidelines for reducing anesthesia medication errors and adverse drug events in dentistry (part 2).
Wang GS, Reynolds KM, Banner W, et al. Acad Ped. 2020;20:327-332.
Using a national surveillance system to identify adverse events A(Es) involving common oral over-the-counter (OTC) cough and cold medications, an expert panel evaluated and assigned causal relationships between AEs and active ingredients in the medications. Of the 4,756 adverse events identified, 10.8% were due to a medication error; nearly all of these errors (93.2%) were attributed to the wrong dose of medication. The most common medication errors involved diphenhydramine and dextromethorphan. Almost half of medication errors (45.8%) involved children between the ages of 2 and 5 years old and involved administration by either a parent (45%) or alternative caregiver (28.8%).  Continued standardization of medication measuring devices, concentrations and units, as well as consumer education, is needed to further decrease medication errors from these common OTC medications.
Ann D. Gaffey, RN, MSN, CPHRM, DFASHRM is the President of Healthcare Risk and Safety Strategies, LLC. Bruce Spurlock, MD is the President and CEO of Cynosure Health. We spoke with them about their role in the development of the Making Healthcare Safer III Report and what new information they think audiences will find particularly useful and interesting.
Dharmarajan TS, Choi H, Hossain N, et al. J Am Med Dir Assoc. 2020;21:355-360.
Polypharmacy is a predictor of medication errors in older adults.  Deprescribing is one approach to managing polypharmacy by reducing the dosage or number of medications and thereby reducing the risk for adverse drug events.  This study reported successful deprescribing in both long-term care and outpatient encounters, with an average of 1.3 deprescribed medications per encounter.
Holden RJ, Campbell NL, Abebe E, et al. Res Social Adm Pharm. 2020;16:54-61.
This usability study examined whether older adults could use a mobile application to consider the risks and benefits of anticholinergics, a high-risk medication class. The 23 participants reported an overall high usability for the application, suggesting that mobile health information technology has potential to engage patients in safety.
Kaisey M, Solomon AJ, Luu M, et al. Mult Scler Relat Disord. 2019;30:51-56.
This retrospective study of patients with a diagnosis of multiple sclerosis found that nearly 20% had been misdiagnosed and did not have the disease. The authors highlight the risks from misdiagnosis including exposure to high-risk medications with resultant adverse drug events and delay in correct treatment for patient conditions.